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| http://dx.doi.org/10.1136/bmj.1.5028.1162 | DOI Listing |
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Label-free electrochemical assessment of human serum and cancer cells to determine the folate receptor cancer biomarker.
Bioelectrochemistry
December 2024
Louisiana Cancer Research Center, School of Medicine, 1700 Tulane Ave, New Orleans, Louisiana 70112, USA.
The folate receptor (FR) is a well-known biomarker that is overexpressed in many cancer cells, making it a valuable target for cancer diagnostics and therapeutic strategies. However, identifying cancer biomarkers remains a challenge due to factors such as lengthy procedures, high costs, and low sensitivity. This study presents the development of a novel, cost-effective biosensor designed for the detection of FR.
View Article and Find Full Text PDFAdvances in Dendritic Systems and Dendronized Nanoparticles: Paradigm Shifts in Cancer Targeted Therapy and Diagnostics.
Mol Pharm
December 2024
School of Pharmacy and Technology Management, SVKM's Narsee Monjee Institute of Management Studies (NMIMS), Deemed to be University, Shirpur, Dhule, Maharashtra 425405, India.
Cancer has emerged as a global health crisis, claiming millions of lives annually. Dendrimers and dendronized nanoparticles, a novel class of nanoscale molecules with highly branched three-dimensional macromolecular structures, have gained significant attention in cancer treatment and diagnosis due to their unique properties. These dendritic macromolecules offer a precisely controlled branching architecture, enabling functionalization with specific targeting molecules to enhance the selective delivery of therapeutic agents to tumor cells while minimizing systemic toxicity.
View Article and Find Full Text PDFRevisiting cost-effectiveness of folic acid supplementation in primary stroke prevention in China: considering vitamin B12 deficiency masking issue.
BMC Public Health
December 2024
School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Objectives: To identify the cost-effectiveness of four policy options related to folic acid supplements after considering the side effects of masking vitamin B12 (B12) deficiency in primary stroke prevention for hypertensive patients in China.
Study Design: A cost-effectiveness analysis.
Methods: Four policies were considered: Policy A, Do nothing to address folate status in hypertensive patients at risk for stroke; Policy B, Folate supplementation without pre-screening for vitamin B12 deficiency; Policy C, Folate supplementation with pre-screening all patients for B12 deficiency and add B12 supplements if B12 is deficient; and Policy D, Folate supplementation only for those whose folate is deficient, pre-screen all patients for both B12 and folate deficiencies and add B12 supplements if B12 is deficient.
Cognitive benefits of folic acid supplementation during pregnancy track with epigenetic changes at an imprint regulator.
BMC Med
December 2024
School of Biomedical Sciences, Biomedical Sciences Research Institute, Ulster University, Coleraine, Northern Ireland, BT52 1SA, UK.
Background: The human ZFP57 gene is a major regulator of imprinted genes, maintaining DNA methylation marks that distinguish parent-of-origin-specific alleles. DNA methylation of the gene itself has shown sensitivity to environmental stimuli, particularly folate status. However, the role of DNA methylation in ZFP57's own regulation has not been fully investigated.
View Article and Find Full Text PDFA qualitative assessment of barriers to iron and folic acid supplementation among pregnant women in Botswana.
BMC Public Health
December 2024
Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Background: Antenatal iron and folic acid (IFA) supplementation remains an effective strategy in the prevention of maternal anemia and low birthweight and is universally recommended by WHO. However, uptake of IFA has varied globally due to challenges with acceptability, supply and distribution, counselling and knowledge, and access to health services. In Botswana, nearly one-third of pregnant women engaged in antenatal care do not receive IFA, despite it being standard of care.
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