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An update on the pharmacotherapy of postpartum depression.
Int J Gynaecol Obstet
November 2024
Department of Pharmacology, JIPMER, Pondicherry, India.
Extensive research has been conducted on postpartum depression (PPD) over the past century, and yet no definitive answer regarding its etiopathogenesis, risk factors, genetic predilection, and treatment has been found. The few preclinical and clinical studies propose that maternal brain adaptations to the endocrinological, immunological, and behavioral changes and external sociodemographic risk factors in the perinatal period make women more vulnerable to anxiety and depression. Irrespective of the cause, a dilemma exists regarding the type of help to provide postpartum mothers.
View Article and Find Full Text PDFFrom antidepressants and psychotherapy to oxytocin, vagus nerve stimulation, ketamine and psychedelics: how established and novel treatments can improve social functioning in major depression.
Front Psychiatry
October 2024
Molecular Psychiatry Lab, Faculty of Science and Medicine, University of Freiburg, Villars-sur-Glâne, Switzerland.
Social cognitive deficits and social behavior impairments are common in major depressive disorder (MDD) and affect the quality of life and recovery of patients. This review summarizes the impact of standard and novel treatments on social functioning in MDD and highlights the potential of combining different approaches to enhance their effectiveness. Standard treatments, such as antidepressants, psychotherapies, and brain stimulation, have shown mixed results in improving social functioning, with some limitations and side effects.
View Article and Find Full Text PDFUnderstanding and treating postpartum depression: a narrative review.
Int Clin Psychopharmacol
June 2024
Department of Clinical Neurosciences, Vita-Salute San Raffaele University, Milan.
Article Synopsis
- Postpartum depression (PPD) is a common but complex condition influenced by hormonal changes, brain chemistry, and other factors, and is increasingly recognized as distinct from major depressive disorder.
- Traditional treatments like selective serotonin reuptake inhibitors (SSRIs) such as sertraline are commonly used, but new medications like brexanolone and zuranolone have been approved, with ongoing research into newer neurosteroids and alternative therapies like esketamine.
- A more personalized approach to treatment, incorporating both medication and non-drug methods like brain stimulation and light therapy, is becoming standard in managing PPD.
Role of Single Nucleotide Polymorphism-Related Genes in Tumour Immune Cell Infiltration and Prognosis of Cutaneous Melanoma.
Biomed Res Int
May 2023
Department of Dermatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China.
Background: Advances in cancer research have allowed for early diagnosis and improved treatment of cutaneous melanoma (CM). However, its invasiveness and recurrent metastasis, along with rising resistance to newer therapies, have lent urgency to the search for novel biomarkers and the underlying molecular mechanisms of CM.
Methods: Single nucleotide polymorphism- (SNP-) related genes were obtained from the sequencing data of 428 CM samples in The Cancer Genome Atlas.
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