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The JNK Signaling Pathway Regulates Seizures Through ENT1 in Pilocarpine-Induced Epilepsy Rat Model.
CNS Neurosci Ther
December 2024
The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, Guizhou, China.
Objective: The study investigates whether the expression and function of ENT1 can be regulated by inhibiting the JNK signaling pathway, thereby altering the levels of extracellular adenosine and glutamate in neurons, and subsequently affecting the progression of epilepsy.
Methods: The adult male SD rats were randomly divided into four groups: EP + SP600125 group, EP + DMSO group, EP group, and normal control group. The expression levels of ENT1, p-JNK, and JNK in the hippocampus of rats from each experimental group were detected using Western blotting technology.
Efficacy of Low-Dose Ketamine and Propofol in the Treatment of Experimental Refractory Status Epilepticus on Male Rats.
J Neurosci Res
November 2024
Department of Physiology, Hamidiye Faculty of Medicine, University of Health Sciences, Istanbul, Turkey.
Refractory status epilepticus (RSE) is a condition with serious mortality and morbidity rate, resistant to benzodiazepine and second-line antiepileptic drugs. This study aimed to electrophysiologically investigate the combination of NMDA receptor antagonist ketamine and GABAergic agent propofol in an RSE model induced by lithium-pilocarpine in male Sprague-Dawley rats. Seventy-two male Sprague-Dawley rats were divided into nine groups.
View Article and Find Full Text PDFEffect of trans 4-butylcyclohexane carboxylic acid (4-BCCA) upon neurodegeneration, oxidative stress related to epileptogenesis in pilocarpine-induced status epilepticus.
Epilepsy Res
January 2025
UCL Queen Square institute of Neurology, Neurology Clinical & Experimental Epilepsy, London, United Kingdom.
Article Synopsis
- - The study investigates the effect of 4-butylcyclohexane carboxylic acid (4-BCCA), a potential epilepsy treatment, in comparison to standard antiseizure medications in a rat model of status epilepticus.
- - 4-BCCA demonstrated effective seizure control and neuroprotection, with the best results observed when combined with the medication perampanel, showing improved memory retention and neuronal viability.
- - The findings suggest that 4-BCCA could be a promising therapeutic option for managing seizures and reducing neurodegeneration in epilepsy, warranting further investigation.
Efficacy of combined administration of Baekhogainsam-Tang and low-dose pilocarpine on frequent intractable xerostomia: Study protocol for a randomized controlled trial.
PLoS One
November 2024
Department of Otolaryngology-Head and Neck Surgery, Kyung Hee University School of Medicine, Kyung Hee University Medical Center, Seoul, Korea.
Background: Intractable xerostomia is defined as the subjective perception of dry mouth and persistent salivary gland hypofunction. Pilocarpine is an approved salivary sialagogue that is frequently prescribed for the treatment of intractable xerostomia; however, it often exhibits more side effects at high-doses and limited effectiveness at low-doses. Baekhogainsam-Tang (BIT) is a common herbal formula used by patients complaining of sore throats and thirst.
View Article and Find Full Text PDFAn updated systematic review of pharmacological treatments for presbyopia.
Adv Ophthalmol Pract Res
September 2024
Department of Ophthalmology, Hospital of Lithuanian University of Health Sciences, Kaunas Clinics, Kaunas, Lithuania.
Background: Presbyopia, a common age-related condition affecting near vision, impacts over a billion people worldwide. The aim of this paper is to review the main reports and results of clinical trials, comparing the newest pharmacological treatment options for presbyopia, their mechanisms of action, and possible side effects.
Main Text: Pharmacological approaches, involving eye drops that target the underlying mechanisms of presbyopia, have gained growing interest.
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