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Qualitative evaluation of magnetic resonance imaging features in aneurysmal bone cysts after percutaneous cryoablation.
Pediatr Radiol
March 2025
Division of Interventional Radiology, Department of Radiology, Boston Children's Hospital, Longwood Ave., Boston, MA, 02492, USA.
Background: Aneurysmal bone cysts (ABCs) are benign vascular lesions commonly affecting the pediatric population.
Objective: To assess magnetic resonance imaging (MRI) features of ABCs after percutaneous cryoablation.
Materials And Methods: A retrospective review of the hospital's electronic medical record database was conducted to identify patients who underwent percutaneous image-guided cryoablation for aneurysmal bone cysts between March 2014 and April 2024.
Inhibition of bone morphogenetic protein 4 alleviates angiotensin II-induced abdominal aortic aneurysm by reducing inflammation and endothelial-mesenchymal transition.
Atherosclerosis
February 2025
Department of Cardiology, Zhejiang Hospital, Hangzhou, Zhejiang 310013, China. Electronic address:
Background And Aims: Abdominal aortic aneurysm (AAA) is one of the most common fatal macrovascular diseases worldwide which pathogenesis is still not well clarified. In this study, we systematically investigated the alternations of endothelial cell (ECs) functions and phenotypes by single-cell RNA sequencing in angiotensin (Ang) II-induced AAA mice models.
Method And Results: According to 10 × single-cell sequencing analysis, we revealed that ECs inflammation and endothelial-mesenchymal transition (EndoMT) were involved in the progress of Ang II-induced AAA.
Abdominal aortic aneurysm is a systemic and generalized arteriomegaly in mice and humans.
Sci Rep
March 2025
Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Although the pathogenesis of abdominal aortic aneurysm (AAA) remains largely unclear, evidence is accumulating to suggest the systemic nature of this disease. Here, we comprehensively assessed the whole aortic tree with its major branches based on computed tomography angiography (CTA) in AAA patients compared to ascending thoracic aortic aneurysm (ATAA) patients and nonaneurysmal controls, as well as in an original mouse model of AAA in Lkb1;Myh11-Cre/ERT2 mice. The morphology and dimensions of the whole aorta (at different levels) and its major branches were compared among 47 AAA patients, 47 ATAA patients, and 46 nonaneurysmal controls based on CTA images.
View Article and Find Full Text PDFCorrecting Lab Misinterpretations of Variants of Unknown Significance: A Case Study of EMILIN1 Variants in an Autosomal Recessive Disorder.
Cureus
February 2025
Medical Genetics, Vanderbilt University Medical Center, Nashville, USA.
A nine-month-old male was referred with short stature, tortuosity in multiple arteries, pulmonary stenosis, and multiple fractures. Trio exome sequencing (ES) revealed a c.275_277delinsTT, p.
View Article and Find Full Text PDFPenetration of the Scalp by the Bent Fragment of a Pre-installed Titanium Mini-Plate Due to a Minor Head Injury: A Case Report.
Cureus
February 2025
Neurosurgery, Shizuoka Welfare Hospital, Shizuoka, JPN.
Titanium mini-plates are commonly used for bone flap fixation in craniotomy and are particularly essential for covering burr holes. Plate exposure through the scalp may occur because of scalp thinning caused by infection or local ischemia, and penetration of the scalp by a titanium mini-plate that had been bent by a minor head injury are rare. A 69-year-old man who had undergone covering of a burr hole in the calvarium by a titanium plate for clipping of a ruptured aneurysm 17 years ago was referred to our clinic to examine metal protruding through the scalp.
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