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The term "Paramunity" summarizes all non-pathogen specific mechanisms of the defence against infections in man and animal, such as phagocytosis, interference, antibiosis, activation of the lymphopoietic cell system and of lysosomal enzymes, stimulation of humoral factors etc. Examples for the induction of a paramunity are described. After an oral or inhalatory administration of polyvalent vaccines prepared from inactivated bacteria to mice, the rate of phagocytosis of the peritoneal or alveolar macrophages increased significantly.
View Article and Find Full Text PDFThe most important advantage of local immunization is the non-specific effect. The active protection test in mice shows an immunity against oral infection with virulent Salmonella typhimurium bacteria after oral immunization with heterologous inactivated enterobacteria. We observed the same non-specific protection in a viral model.
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