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Visualizing lipid nanoparticle trafficking for mRNA vaccine delivery in non-human primates.
Mol Ther
January 2025
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, Harvard University, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Department of Materials Science of Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:
mRNA delivered using lipid nanoparticles (LNPs) has become an important subunit vaccine modality, but mechanisms of action for mRNA vaccines remain incompletely understood. Here, we synthesized a metal chelator-lipid conjugate enabling positron emission tomography (PET) tracer labeling of LNP/mRNA vaccines for quantitative visualization of vaccine trafficking in live mice and non-human primates (NHPs). Following intramuscular injection, we observed LNPs distributing through injected muscle tissue, simultaneous with rapid trafficking to draining lymph nodes (dLNs).
View Article and Find Full Text PDFInvestigation and Characterization of Eco-Technological Synthesis of Spherical TiO Nanoparticles from Thalassia hemprichi and Analysis of Biomedical Properties.
Appl Biochem Biotechnol
January 2025
Ethnopharmacology and Algal Biotechnology Laboratory, Department of Botany, School of Life Sciences, Periyar University, Salem, Tamil Nadu, 636011, India.
In this present investigation, plant-mediated synthesis of titanium oxide (TiO) nanoparticles was synthesized from seagrass (Thalassia hemprichi) using the hot plate combustion method (HPCM). Synthesized TiO nanoparticles optical, functional, structural, and morphology properties were analyzed by UV-visible spectroscopy, Fourier transform infrared spectroscopy (FT-IR), powder X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX). SEM analysis confirmed the spherical shape of the TiO nanoparticles were observed in various sizes, viz.
View Article and Find Full Text PDFDesferrioxamine B (DFOB) assisted nanofiltration system for the recycling of gallium from low concentrated wastewater.
Water Res
March 2025
Helmholtz-Zentrum Dresden-Rossendorf, Helmholtz Institute Freiberg for Resource Technology, Bautzner Landstrasse 400, Dresden 01328, Germany.
Gallium is classified as a technology metal as it is important for technological innovations. It is also referred to as a strategic metal, which emphasizes its economic relevance. In addition, gallium is a critical raw material that is strategically important but only available in limited quantities.
View Article and Find Full Text PDFUnlocking the potential of the thioamide group in drug design and development.
Future Med Chem
January 2025
Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Plant protein dominant enteral nutrition, containing soy and pea, is non-coagulating after gastric digestion in contrast to casein dominant enteral nutrition.
Food Res Int
December 2024
Danone Research & Innovation, Utrecht, The Netherlands. Electronic address:
Enteral Nutrition (EN) is used for the dietary management of patients requiring tube feed and who are at risk of disease related malnutrition. Previously, EN with a dairy-dominant p4 protein blend (DD-P4: 20% soy, 20% pea, 25% casein and 35% whey) was shown to not coagulate in the stomach, increase gastric emptying rate and reduce gastric residual volume compared to EN with casein-dominant protein blends (CD; 80% casein and 20% whey), which is relevant for upper gastrointestinal tolerance. In line with the EAT-Lancet report, a new plant-dominant protein blend (PD-P4: 46% soy, 32% pea, 16% casein and 6% whey) was developed.
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