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Quinoxaline 1,4-di--oxide Derivatives as New Antinocardial Agents.
Molecules
September 2024
Laboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Boulevard del Maestro, s/n, Esq. Elías Piña, Reynosa 88710, México.
Mycetoma is currently considered as a neglected tropical disease. The incidence of mycetoma is unknown but most of the worldwide cases are present in the "mycetoma belt" including countries like Mexico, India, Senegal, and others. The treatment of mycetoma depends on the etiological agent responsible for the case.
View Article and Find Full Text PDFDirect 16S/ITS rRNA Gene PCR Followed by Sanger Sequencing for Detection of Mycetoma Causative Agents in Dakar, Senegal: A Pilot Study Among Patients with Mycetoma Attending Aristide Le Dantec University Hospital.
Mycopathologia
September 2024
IHU Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France.
Article Synopsis
- Mycetoma is a type of infection caused by fungi or bacteria, and identifying the specific agent is crucial for treatment success.
- This study analyzed 32 mycetoma samples from patients, using advanced genetic techniques to identify the pathogens, focusing on different regions of DNA for various grain types.
- The findings revealed a 59.4% identification success rate, with the fungal pathogen Madurella mycetomatis being the most common, and two potential new agents were also discovered.
Fungal mycetoma and pregnancy: An association with costly and difficult management, about a case.
PLoS Negl Trop Dis
November 2023
Department of Dermatology, Hospital Institute of Social Hygiene, Dakar, Senegal.
Article Synopsis
- Mycetomas are infectious diseases commonly found in poor, rural areas of tropical and subtropical regions, primarily affecting vulnerable populations.
- A case involved a 39-year-old woman with a fungal mycetoma during pregnancy, which worsened but eventually resulted in a positive outcome despite high medical costs.
- The patient underwent surgery and antifungal treatment for the mycetoma caused by Madurella mycetomatis, achieving positive results for both her pregnancy and the infection.
Diagnostics to support mycetoma management-Development of two target product profiles.
Trop Med Int Health
December 2022
Department of Medical Microbiology & Infectious Diseases, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
Objective: Mycetoma is a neglected tropical disease caused by more than 70 different microorganisms and identified by the WHO as one of the high-priority diseases for developing diagnostic tests. To ensure the production of diagnostic assays for use by clinical staff in endemic regions, target product profiles (TPPs) were designed.
Methods: We describe the development of two TPPs: one for a diagnostic test able to identify the causative agent of mycetoma and another that would determine when treatment could be stopped.
[Extrapodal mycetomas in Senegal: epidemiological, clinical and etiological study of 82 cases diagnosed from 2000 to 2020].
Med Trop Sante Int
March 2022
Service de dermatologie, Centre hospitalier universitaire Aristide Le Dantec, Dakar, Sénégal.
Objectives: Although the foot remains the main localization of mycetomas, extrapodal attacks, which are rarely studied, are also possible and occur either initially or following an extension. The objectives were to describe the epidemiological, clinical and etiological features of extrapodal mycetomas in Senegal.
Methodology: Cross-sectional and retrospective study with multicentric enrollment in four reference department, two of which are in dermatology and two in orthopedics and traumatology.
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