Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Deep learning-based discovery of compounds for blood pressure lowering effects.
Sci Rep
January 2025
School of Pharmacy, Guilin Medical University, Guilin, 541199, China.
The hypotensive side effects caused by drugs during their use have been a vexing issue. Recent studies have found that deep learning can effectively predict the biological activity of compounds by mining patterns and rules in the data, providing a potential solution for identifying drug side effects. In this study, we established a deep learning-based predictive model, utilizing a data set comprised of compounds known to either elevate or lower blood pressure.
View Article and Find Full Text PDFThe Antinociceptive Effects and Sex-Specific Neurotransmitter Modulation of Metformin in a Mouse Model of Fibromyalgia.
Cells
November 2024
Department of Physiology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Fibromyalgia (FM) is a chronic and debilitating condition characterized by diffuse pain, often associated with symptoms such as fatigue, cognitive disturbances, and mood disorders. Metformin, an oral hypoglycemic agent, has recently gained attention for its potential benefits beyond glucose regulation. It has shown promise in alleviating neuropathic and inflammatory pain, suggesting that it could offer a novel approach to managing chronic pain conditions like FM.
View Article and Find Full Text PDFTargeting Yes-Associated Protein (YAP) in Breast Cancer: In Silico Molecular Dynamics, Luminescence-Based In Vitro, and In Vivo Validation of Rauvolfia tetraphylla-Derived Inhibitors.
Luminescence
December 2024
Biological and Environmental Sensing Research Unit, King Abdullah Institute for Nanotechnology, King Saud University, Riyadh, Saudi Arabia.
The study aims to elucidate the pharmacological mechanism of Rauvolfia tetraphylla against breast cancer through a comprehensive, multi-faceted approach. This includes molecular docking, molecular dynamics, and experimental validation. Initial screening via ADME analysis and network pharmacology identified key compounds and potential targets.
View Article and Find Full Text PDFSelect terpenes from Cannabis sativa are antinociceptive in mouse models of post-operative pain and fibromyalgia via adenosine A receptors.
Pharmacol Rep
December 2024
Department of Pharmacology, College of Medicine, University of Arizona, LSN563, 1501 N. Campbell Ave, Box 245050, Tucson, AZ, 85724, USA.
Background: Terpenes from Cannabis show promise for pain management. Our lab found that the terpenes geraniol, linalool, β-caryophyllene, and α-humulene relieve chemotherapy-induced peripheral neuropathy via Adenosine A receptors (AR). This suggests terpenes as potential non-opioid, non-cannabinoid therapeutics.
View Article and Find Full Text PDFNew ways to repurpose salmeterol in an animal model of fibromyalgia.
Fundam Clin Pharmacol
February 2025
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
Article Synopsis
- Fibromyalgia (FM) is a chronic pain syndrome linked to mood issues, sleep problems, and cognitive decline, possibly due to central pain processing dysfunction and neurotransmitter imbalances.* -
- In a study involving rats, reserpine was used to induce FM-like symptoms, revealing issues like increased pain sensitivity, depressive behaviors, and biochemical disturbances, which were reversed with the administration of salmeterol, a β2 receptor agonist.* -
- The findings suggest that treatments targeting β2 receptors, like salmeterol, could be an effective approach for managing symptoms associated with fibromyalgia.*
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!