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Utility of I-HLX58-Der for the Precision Treatment: Evaluation of a Preclinical Radio-Antibody-Drug-Conjugate Approach in Mouse Models.
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Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai, 200032, People's Republic of China.
Purpose: None of the antibody-drug conjugates (ADCs) targeting Claudin 18.2 (CLDN18.2) have received approval from regulatory authorities due to their limited clinical benefits.
View Article and Find Full Text PDFDosimetry of Continuous Random Motion in High Dose Rate Strontium-90 Plesiotherapy.
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Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, Missouri, USA.
Strontium-90 plesiotherapy delivers high doses of radiation to superficial lesions (<3 mm depth) with excellent sparing of deeper tissues. The sealed-source applicator tip is circular and 8-10 mm in diameter. Larger treatment fields are treated with multiple overlapping fields.
View Article and Find Full Text PDFWhich PSMA PET/CT interpretation criteria most effectively diagnose prostate cancer? a retrospective cohort study.
BMC Med Imaging
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Department of Urology, The First Hospital of Shanxi Medical University, Taiyuan, 030000, China.
Background: PSMA PET/CT emerges as a pivotal technology in the diagnostic landscape of prostate cancer (PCa). It offers a suite of imaging interpretation criteria, notably the maximum standardized uptake value (SUVmax), the molecular imaging prostate-specific membrane antigen score (miPSMA score), and the PSMA reporting and data system (PSMA-RADS). Identifying the most valuable criteria for diagnosing PCa and standardizing imaging interpretation across various tracers is an unresolved question.
View Article and Find Full Text PDFReal-time trajectory imaging of alpha particles emitted from actinium-225 and its daughter radionuclides.
Sci Rep
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Faculty of Science and Engineering, Waseda University, Tokyo, Japan.
In targeted alpha-particle therapy, actinium-225 (Ac-225) has emerged as a radionuclide of potential, driving extensive efforts to develop innovative radiopharmaceuticals. High-resolution imaging of alpha particles is required for precisely detecting alpha-emitting radionuclides in cellular environments and small organs. Here, we report real-time trajectory imaging of alpha particles emitted by Ac-225 and its daughter radionuclides, utilizing an alpha particle trajectory imaging system.
View Article and Find Full Text PDFNomogram models for predicting outcomes in thyroid cancer patients with distant metastasis receiving iodine therapy.
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Department of Nuclear Medicine, Zhejiang Cancer Hospital, Hangzhou, 310022, Zhejiang, China.
This study aimed to establish and validate prognostic nomogram models for patients who underwent I therapy for thyroid cancer with distant metastases. The cohort was divided into training (70%) and validation (30%) sets for nomogram development. Univariate and multivariate Cox regression analyses were used to identify independent predictors for overall survival (OS) and progression-free survival (PFS).
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