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Electromembrane extraction of multi-class prohibited/restricted veterinary drugs from food samples - Exploring liquid membrane composition.
Food Chem
December 2024
West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China. Electronic address:
Effective monitoring of veterinary drug residues in food is essential for legislation compliance and food safety, yet remains challenging due to low concentrations and complex matrices. This study introduced a miniaturized 96-well electromembrane extraction (EME) technique for pre-concentration and isolation 80 prohibited/restricted veterinary drugs from honey samples. Three liquid membranes were developed and characterized: V1 ("V" for veterinary), a mixture of 2-undecanone and 0.
View Article and Find Full Text PDF3D Bioprintable Self-Healing Hyaluronic Acid Hydrogel with Cysteamine Grafting for Tissue Engineering.
Gels
November 2024
Department of Chemical and Biomolecular Engineering, Seoul National University of Science and Technology, Seoul 01811, Republic of Korea.
The abundance of hyaluronic acid (HA) in human tissues attracts its thorough research in tissue regenerating scaffolds and 3D bioprintable hydrogel preparation. Though methacrylation of HA can lead to photo-crosslinkable hydrogels, the catalyst has toxicity concerns, and the hydrogel is not suitable for creating stable complex 3D structures using extrusion 3D bioprinting. In this study, a dual crosslinking on methacrylated HA is introduced, using cysteamine-grafted HA and varying concentrations of 2-hydroxy ethyl acrylate.
View Article and Find Full Text PDF[Adsorption of Tetracycline in Composite-polluted Water by Biochar from Industrial Production].
Huan Jing Ke Xue
January 2025
School of Environment and Natural Resources, Zhejiang University of Science and Technology, Hangzhou 310023, China.
Compared to the laboratory preparation of biochar, there is less research on the adsorption of antibiotics by industrial production of biochar in water. In this study, three types of industrial production biochar （peanut shell biochar, sludge biochar, and perishable waste biochar） were selected, and their adsorption performance for tetracycline in composite-polluted water was systematically studied. The results indicated that the Freundlich equation could well fit the adsorption isotherms of the three types of biochar for tetracycline.
View Article and Find Full Text PDFMolecular mechanism of action of tetracycline-loaded calcium phosphate nanoparticle to kill multi-drug resistant bacteria.
Biochim Biophys Acta Gen Subj
January 2025
Department of Biochemistry and Biophysics, University of Kalyani, Kalyani 741 235, West Bengal, India. Electronic address:
Article Synopsis
- The study explores the use of calcium phosphate nanoparticles (CPNP) to enhance the effectiveness of the antibiotic tetracycline (Tet) against tetracycline-resistant bacteria, demonstrating its superior bactericidal properties compared to the standard tetracycline.
- Experimental methods showed that Tet-CPNP exhibits a higher binding affinity to bacterial ribosomes and disrupts their structure, leading to the degradation of the ribosomes and blocking protein synthesis.
- The findings suggest that Tet-CPNP could potentially overcome the challenges posed by tetracycline-resistant bacteria, revitalizing the clinical use of this established antibiotic.
Identification of IspD as a novel target for tuberculosis treatment using compound M6.
Front Microbiol
November 2024
Ningxia Key Laboratory of Clinical and Pathogenic Microbiology, The School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.
Introduction: Tuberculosis (TB) is a serious infectious disease that endangers human health, and TB becomes more difficult in eradiation due to its multidrug resistance (MDR). The objective of this research was to identify novel targets for treating TB.
Methods: A 2-fold serial dilution method was used to determine minimal inhibitory concentrations (MIC) of compound M6 against ().
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