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Disorders of gastric motility.

Lancet Gastroenterol Hepatol

November 2024

Vatche and Tamar Manoukian Division of Digestive Diseases, G. Oppenheimer Center for Neurobiology of Stress and Resilience, Clinical Studies and Database Core, Goodman-Luskin Microbiome Center, David Geffen School of Medicine, University College Los Angeles, Los Angeles, CA, USA. Electronic address:

Gastroparesis is a disorder of delayed gastric emptying with associated symptoms of postprandial fullness, early satiety, nausea, vomiting, bloating, and abdominal pain. Functional dyspepsia is an upper gastrointestinal disorder of gut-brain interaction that presents with similar symptoms but is defined according to symptom patterns rather than gastric motor dysfunction. Although delayed gastric emptying is a defining feature of gastroparesis, other aspects of gastric neuromuscular dysfunction, such as gastric accommodation and visceral hypersensitivity might contribute to symptoms.

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Extended-period AOSLO imaging in the living human retina without pupil dilation: a feasibility study.

Biomed Opt Express

September 2024

Department of Experimental Psychology, University of Oxford, Anna Watts Building, Radcliffe Observatory Quarter, Woodstock Road, Oxford OX2 6GG, United Kingdom.

imaging using an adaptive optics scanning laser ophthalmoscope (AOSLO) is challenging, especially over extended periods. Pharmacological agents, administered as eye drops, are commonly used to dilate the pupil and paralyse accommodation, to improve image quality. However, they are contraindicated in some scenarios.

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Aim: Gastric emptying scintigraphy is used to assess patients with symptoms of dyspepsia or gastroparesis. An alteration of fundus accommodation may explain these symptoms. The aim of this study was to determine the accommodation in gastric emptying scintigraphy studies performed in our institution.

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Article Synopsis
  • * Out of 191 adult ARDS patients on VV ECMO, 69% successfully switched to PSV, which led to better respiratory mechanics, increased compliance, and lower pulmonary shunt fraction.
  • * The findings suggest that PSV during VV ECMO is not only possible but may improve patient outcomes, with 94% of those transitioned to PSV being weaned from ECMO and a high percentage being discharged alive from ICU.
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Background: Absent "organic" disease, dyspeptic symptoms may arise from abnormal gastric sensation, accommodation, motility or emptying (GE). Extensive gastric sensorimotor evaluation is rarely undertaken because testing is prolonged, invasive, poorly tolerated or unavailable.

Aims: To investigate whether gastric antral motor function, evaluated with scintigraphy, predicts GE.

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