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Pharmacologic Adjuncts for Neonatal Tracheal Intubation: The Evidence Behind Premedication.
Neoreviews
December 2023
Department of Pediatrics, Division of Neonatology, University of Colorado School of Medicine and Children's Hospital of Colorado, Denver, CO.
Article Synopsis
- - Premedication for neonatal tracheal intubation, including analgesia, sedation, and paralytics, can enhance success rates and minimize risks associated with the procedure.
- - This review covers various premedication classes, their indications, administration routes, dosages, and potential side effects in different infant populations.
- - The article highlights the need for guidelines on premedication, especially with the rise in survival of extremely preterm infants, and addresses gaps in established practices during certain medical procedures.
Ketamine Use in the Intubation of Critically Ill Children with Neurological Indications: A Multicenter Retrospective Analysis.
Neurocrit Care
February 2024
Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Background: Ketamine has traditionally been avoided for tracheal intubations (TIs) in patients with acute neurological conditions. We evaluate its current usage pattern in these patients and any associated adverse events.
Methods: We conducted a retrospective observational cohort study of critically ill children undergoing TI for neurological indications in 53 international pediatric intensive care units and emergency departments.
Dopamine D receptor subtype activation reduces the rat cardiac parasympathetic discharge.
Pflugers Arch
December 2020
Laboratorio de Farmacología, Dep. de Fisiología y Farmacología, Facultad de Farmacia, Instituto de Investigación Biomédica de Salamanca (IBSAL), Universidad de Salamanca, 37007, Salamanca, Spain.
The dopaminergic system influences the heart rhythm by inhibiting the rat cardiac sympathetic and parasympathetic neurotransmissions through activation of D-like receptors (encompassing the D, D, and D subtypes). Whereas D receptor subtype activation results in cardiac sympatho-inhibition, the dopamine receptor subtypes involved in rat cardiac vago-inhibition remain unknown. Hence, this study investigated the specific functional role of the D-like receptor subtypes (D, D, and/or D) inhibiting the rat heart cholinergic drive.
View Article and Find Full Text PDFDrug Therapy for Hypertrophic Cardiomypathy: Physiology and Practice.
Curr Cardiol Rev
July 2016
New York University Langone Medical Center, 530 First Avenue, NYC, NY 10016, USA.
HCM is the most common inherited heart condition occurring in 1:500 individuals in the general population. Left ventricular outflow obstruction at rest or after provocation occurs in 2/3 of HCM patients and is a frequent cause of limiting symptoms. Pharmacologic therapy is the first-line treatment for obstruction, and should be aggressively pursued before application of invasive therapy.
View Article and Find Full Text PDFHCM is the most common inherited heart condition occurring in 1:500 individuals in the general population. Left ventricular outflow obstruction at rest or after provocation occurs in 2/3 of HCM patients and is a frequent cause of limiting symptoms. Pharmacologic therapy is the first-line treatment for obstruction, and should be aggressively pursued before application of invasive therapy.
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