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Ideal animal models according to multifaceted mechanisms and peculiarities in neurological disorders: present and challenges.
Arch Pharm Res
December 2024
College of Pharmacy, Chung-Ang University, 84 Heukseok-Ro, Dongjak-Gu, Seoul, 06974, Republic of Korea.
Neurological disorders, encompassing conditions such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), pose a significant global health challenge, affecting millions worldwide. With an aging population and increased life expectancy, the prevalence of these disorders is escalating rapidly, leading to substantial economic burdens exceeding trillions of dollars annually. Animal models play a crucial role in understanding the underlying mechanisms of these disorders and developing effective treatments.
View Article and Find Full Text PDFThe genus Rhinoceromyia Grichanov gen. nov. is described from the tropical forest of southeastern Guinea to accommodate a new species, Rhinoceromyia dubrovskii Grichanov sp.
View Article and Find Full Text PDFCo-Existing Ectopic Cortisol-Producing Adenoma and Retroperitoneal Schwannoma, a Rare Case Report.
Diabetes Metab Syndr Obes
November 2024
Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
Background: Ectopic cortisol-producing adrenocortical adenoma (ECPA) is extremely rare, with only a few cases reported. Retroperitoneal schwannoma is also uncommon, accounting for only 0.7-5% of all schwannomas.
View Article and Find Full Text PDFUnraveling the Pleiotropic Role of High-Density Lipoproteins (HDLs) in Autoimmune Rheumatic Diseases.
Int J Rheumatol
November 2024
Programa de Pós-Graduação em Medicina, Universidade Nove de Julho (UNINOVE) 01525-000, São Paulo, Brazil.
Autoimmune rheumatic diseases (ARDs) exhibit an elevated incidence of cardiovascular disease (CVD). The elevation of inflammatory and immune stress accompanying ARDs contributes to atherosclerosis development and alterations in lipid metabolism and lipoprotein profile add to cardiovascular (CV) risk. The plasma concentration of high-density lipoprotein cholesterol (HDLc) is inversely related to CVD and serves as a discriminator of CV risk.
View Article and Find Full Text PDFAtomistic simulation of primary microstructure formation in metals during crystallization from the melt.
Sci Rep
November 2024
National University of Science and Technology "MISIS", Leninsky pr. 4, Moscow, Russia, 119049.
Additive manufacturing of metallic parts by Selective Laser Melting (SLM) implies high temperature gradients and small volume of the melt bath. These conditions make the process scales close to those available for state-of-the-art massively parallel atomistic simulations. In the paper, the microscopic mechanisms responsible for the formation of primary microstructure during molten metal solidification are investigated using classical molecular dynamics (CMD).
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