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Management of Hyperleukocytosis.
Curr Treat Options Oncol
February 2016
Division of Pediatric Oncology, A. Gemelli Hospital, Catholic University of Rome, Largo A. Gemelli 8, 00168, Rome, Italy.
Hyperleukocytosis has a high morbidity index. The involvement of the respiratory or central nervous system and the metabolic derangements accompanying tumor lysis are responsible for early mortality. Standard care for acute hyperleukocytosis must include cytoreduction, proper supportive care, and prevention of tumor lysis.
View Article and Find Full Text PDF[TRALI is an overlooked severe complication related to blood transfusion].
Ugeskr Laeger
March 2014
FBE Klinisk Immunologi, Aalborg Universitetshospital, Urbansgade 32, 9100 Aalborg.
Transfusion-related acute lung injury (TRALI) is recognized as the most frequent cause of transfusion-related severe morbidity and mortality. TRALI is characterized by post-transfusional respiratory distress, hypoxaemia and radiographic verified lung infiltration, in the absence of sign of circulatory overload. TRALI is predominantly triggered by human leukocyte antigen or human neutrophil antigen (HNA) antibodies from the transfused blood component.
View Article and Find Full Text PDFWe report on a case of delayed hemolytic transfusion reaction (DHTR) occurred 7 days after an erythrocytapheresis or eritroexchange procedure (EEX) treated with rituximab and glucocorticoids in a 15-years old patient with sickle cell disease. EEX was performed despite a previous diagnosis of alloimmunization, in order to reduce hemoglobin S rate before a major surgery for avascular necrosis of the femoral head. A first dose of rituximab was administered before EEX.
View Article and Find Full Text PDF[Transfusion-related acute lung injury. A case report].
Ann Fr Anesth Reanim
December 2004
Département d'anesthésie-réanimation III, hôpital Saint-André, 1, rue Jean-Burguet, 33000 Bordeaux, France.
Acute lung injury is a common adverse effect of massive blood transfusion, responsible for 17% of the deaths due to transfusion in France. A cardiac origin is often suspected. We report a case of post-transfusional pulmonary oedema in a cirrhotic patient, which could be related to a non-cardiac and underdiagnosed aetiology: the so-called transfusion related acute lung injury (TRALI).
View Article and Find Full Text PDFImpact of TT virus infection in acute and chronic, viral- and non viral-related liver diseases.
J Hepatol
July 2000
CNR on Viral Hepatitis, Necker Institute, Necker University, Paris, France.
Background/aims: The prevalence and pathogenicity of TT virus, recently identified in patients with non A-non G post-transfusional hepatitis, are questioned.
Methods: We investigated the impact of this new viral infection in a large series of patients with non A-non G, cryptogenic, non-viral and viral-related, acute and chronic liver diseases (n=577) and blood donors (n=300). TTV DNA was detected in serum by hemi-nested polymerase chain reaction.
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