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An Integrated Strategy for Deciphering the Action Mechanism of Emplastrum: Prescription Analysis- Component Identification- Virtual Screening and Affinity Testing in the Case of Yaoshen Gao.
J Ethnopharmacol
January 2025
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, China. Electronic address:
Ethnopharmacological Relevance: Emplastrum has a long history of use in the clinical practice of traditional Chinese medicine (TCM), valued for its convenient external application and pronounced therapeutic effects. Traditionally, the emplastrum was composed of numerous herbal medicines. The elucidation of their mechanisms of action are of great importance.
View Article and Find Full Text PDFGender dysphoria in a Hispanic pregnant transgender man: Case report and review of literature.
Int J Gynaecol Obstet
January 2025
Endocrinology Division-Department of Medicine, University of Puerto Rico, San Juan, Puerto Rico, USA.
There is limited research concerning the transgender population's health issues, such as gender dysphoria, and disparities within the healthcare system, especially in the Latino or Hispanic population. This study aimed to report the case of a Puerto Rican transgender man who achieved pregnancy without reproductive assistance after cessation of testosterone therapy for 3 months and who in the postpartum period experienced significant gender dysphoria. A narrative literature review was carried out to identify the role of gender dysphoria in pregnancy, lactation, health-related spaces, and mental health.
View Article and Find Full Text PDFEvaluation of polygenic risk scores for hormones and receptors levels in patients with vestibulodynia: a case-control study.
J Sex Med
January 2025
Clinical Obstetric and Gynecological V Buzzi, ASST-FBF-Sacco, Via Castelvetro 24-20124-University of the Study of Milan, Milan, Italy.
Background: Vulvodynia is a multifactorial disease affecting 7%-16% of reproductive-aged women in general population; however, little is still known about the genetics underlying this complex disease.
Aim: To compare polygenic risk scores for hormones and receptors levels in a case-control study to investigate their role in vulvodynia and their correlation with clinical phenotypes.
Methods: Our case-control study included patients with vestibulodynia (VBD) and healthy women.
High-Throughput Effect-Directed Analysis of Androgenic Compounds in Hospital Wastewater: Identifying Effect Drivers through Non-Target Screening Supported by Toxicity Prediction.
Environ Sci Technol
January 2025
Department Exposure Science, Helmholtz Centre for Environmental Research─UFZ, 04318 Leipzig, Germany.
The increasing number of contaminants released into the environment necessitates innovative strategies for their detection and identification, particularly in complex environmental matrices like hospital wastewater. Hospital effluents contain both natural and synthetic hormones that might significantly contribute to endocrine disruption in aquatic ecosystems. In this study, HT-EDA has been implemented to identify the main effect-drivers (testosterone, androsterone and norgestrel) from hospital effluent using microplate fractionation, the AR-CALUX bioassay and an efficient data processing workflow.
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