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Adenocarpine, Marmesin, and Lycocernuine from Ficus benjamina as Promising Inhibitors of Aldose Reductase in Diabetes: A Bioinformatics-Guided Approach.
Appl Biochem Biotechnol
January 2025
Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
Diabetes affects approximately 422 million people worldwide, leading to 1.5 million deaths annually and causing severe complications such as kidney failure, neuropathy, and cardiovascular disease. Aldose reductase (AR), a key enzyme in the polyol pathway, is an important therapeutic target for managing these complications.
View Article and Find Full Text PDFImpact of a lagoon with high anthropic activity on a World Heritage Site.
Environ Monit Assess
January 2025
Department of Earth Science, University of Bizerte-FSB, University of Carthage, 7120, Bizerte, Tunisia.
The Ichkeul-Bizerte Lagoon Complex (IBLC), a critical ecosystem for local biodiversity, faces a pressing threat due to climate change and severe pollution. Despite past conservation efforts, pollution persists, particularly in the Bizerte Lagoon. This study investigated the impact of water dynamics and climatic conditions on heavy metal contamination in the IBLC's sediments.
View Article and Find Full Text PDFGlobal Trends in Prevalence and Future Projections of Pelvic Organ Prolapse: A 30-year Epidemiological Study.
Int Urogynecol J
January 2025
Department of Obstetrics and Gynecology, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, Ningxia, China.
Introduction: Pelvic organ prolapse (POP) is a widespread disease in women. Despite its significant prevalence, there is a lack of comprehensive global studies, emphasizing the urgent need for tailored prevention and treatment approaches. This study aims to examine the global burden of POP from 1990 to 2021 and project future trends using the GBD data.
View Article and Find Full Text PDFCancer therapy and reproductive impact.
Int J Gynaecol Obstet
January 2025
University Hospital Galway, University of Galway, Galway, Ireland.
All patients where the cancer treatment has gonadotoxic potential should be referred for oncofertility advice. The effect of chemotherapy and radiotherapy on the human ovary can vary from no impact to full-blown premature ovarian failure due to hormonal and follicular depletion. Total contraindications to fertility cryopreservation include acute malignancy that requires immediate lifesaving therapy.
View Article and Find Full Text PDFExploring auxiliary liver transplantation in the era of transplant oncology - A proposal for a new liver splitting program (ALERT-50).
Liver Transpl
January 2025
Hepato-biliary-pancreatic Surgery and Liver Transplantation Unit, Padua University Hospital, Padua, Italy.
Total hepatectomy and liver transplantation has emerged as a game-changing strategy in the treatment of several liver-confined primary or metastatic tumors, opening the new era of transplant oncology. However, the expansion of indications is going to worsen the chronic scarcity of organs, and new strategies are needed to enlarge the donor pool. A possible source of organs could be developing split liver transplantation (SLT) programs.
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