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Purpose: The study aimed to identify and assess the methodological quality of essential clinical guidelines for the management of laryngitis and pharyngitis.

Methods: A systematic search of clinical guidelines for the management of laryngitis and pharyngitis was performed in three databases. Methodological quality was assessed according to AGREE II, in which each item in its domains was scored by four independent evaluators.

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Conservative Approach to Treatment of Cyclosporine-Induced Gingival Hyperplasia With Azithromycin and Chlorhexidine.

Cutis

December 2024

Dr. Krevh is from the College of Medicine, Northeast Ohio Medical University, Rootstown. Dr. Korman is from the Department of Dermatology, The Ohio State University Wexner Medical Center, Columbus.

Treatment of symptomatic cyclosporine-induced gingival hyperplasia can be challenging, especially if continued use of cyclosporine is necessary for adequate control of the underlying disease. We outline a simplified approach for conservatively managing cyclosporine-induced gingival hyperplasia using azithromycin and chlorhexidine.

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In-vitro susceptibility of pathogenic and intermediate Leptospira species towards antibiotics and herb extracts.

Trop Biomed

December 2024

Resource Biotechnology Programme, Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300, Kota Samarahan, Sarawak, Malaysia.

Leptospirosis is a severe and potentially fatal re-emerging zoonotic and waterborne disease caused by pathogenic and intermediate species of Leptospira. Given the high global rates of morbidity and mortality associated with this disease, there is an urgent need to explore alternative therapeutic agents to enhance treatment options. This study investigates the anti-leptospiral efficacy of several common antibiotics-penicillin G, doxycycline, ampicillin, amoxicillin, cefotaxime, chloramphenicol, and erythromycin, as well as extracts from local herbs, Hydnophytum formicarum Jack and Boesenbergia stenophylla, against pathogenic and intermediate Leptospira strains.

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Monitoring of ventilation in prone position in a patient diagnosed with scrub typhus and acute respiratory distress syndrome by using an electrical impedance tomography: a case report.

Trop Biomed

December 2024

Department of Critical Care Medicine, The Fourth Affiliated Hospital, School of Medicine, Zhejiang University, No. N1 Shangcheng Avenue, Yiwu, Zhejiang 322000, China.

Scrub typhus is an infectious disease caused by Orientia tsutsugamushi. It is transmitted through bite of chigger mite larvae and presents with symptoms such as fever, myalgia, headache, rash, and a characteristic eschar at the site of mite bites. This report details the case of a woman exhibiting acute febrile illness, bilateral pneumonia, and severe hypoxemia, prompting suspicion of scrub typhus due to the presence of a typical eschar on the pubic mound.

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BACKGROUND Ureaplasma urealyticum (UU) is a common microorganism that has been associated with a variety of obstetric and neonatal complications, such as infertility, stillbirth, histologic chorioamnionitis, neonatal sepsis, respiratory infections, and central nervous system infections. However, it is rare for it to cause severe neonatal asphyxia. This rarity is the focus of our case report, which aims to highlight the potential severity of UU infections in newborns.

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