Sequential timed samples were taken from patients after a single dose of a new cephalosporin--Cefpirome HR810. The patients had been recruited in a multi-centre trial over a 12-month period. Creatinine was estimated in all of these specimens by four different techniques, embodying four different analytical principles. Interference from the drug was evident in the assay depending on the Jaffe reaction. There was also interference in the enzyme-based methods, manifested as increased imprecision due to a non-specified cause thought to be related to the age of the samples. Only the HPLC method guaranteed precise results free from drug interference.
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