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Potential implications of granzyme B in keloids and hypertrophic scars through extracellular matrix remodeling and latent TGF-β activation.
Front Immunol
January 2025
International Collaboration on Repair Discoveries (ICORD) Centre, Vancouver Coastal Health Research Institute (VCHRI), University of British Columbia (UBC), Vancouver, BC, Canada.
Keloid scars (KS) and hypertrophic scars (HS) are fibroproliferative wound healing defects characterized by excessive accumulation of extracellular matrix (ECM) in the dermis of affected individuals. Although transforming growth factor (TGF)-β is known to be involved in the formation of KS and HS, the molecular mechanisms responsible for its activation remain unclear. In this study we investigated Granzyme B (GzmB), a serine protease with established roles in fibrosis and scarring through the cleavage of ECM proteins, as a potential new mediator of TGF-β activation in KS and HS.
View Article and Find Full Text PDFImpact of operating parameters on the electrooxidation of methylene blue and ciprofloxacin: a comprehensive analysis and degradation pathway.
Environ Sci Pollut Res Int
January 2025
Environmental Science and Engineering Department (ESED), Indian Institute of Technology Bombay, Mumbai, 400076, India.
In recent decades, freshwater bodies have experienced significant stress due to the excessive disposal of dyes from textile industries and waste antibiotic discharges from pharmaceutical industries. The continuous disposal of these substances may harm the natural ecosystem and generate antibiotic resistance in living organisms. Conventional treatment facilities are inadequate in treating these contaminants effectively, leading to a focused interest in advanced technologies, such as electrooxidation.
View Article and Find Full Text PDFDetection and quantification of drugs on banknotes by LC-MS/MS with a fast and non-destructive sample preparation: a comparison of three cities.
Forensic Toxicol
January 2025
Morgue Department, Council of Forensic Medicine, Istanbul, Turkey.
Purpose: The analysis of drug residues on some currencies is well-established in the literature. However, there is no published study describing the presence of drug residues on Turkish paper currency.
Methods: This study focused on the analysis of 14 drug residues present on 600 Turkish banknotes collected from three different cities: Ankara, Adana, and Istanbul.
Generative AI in a new era of computer model-informed tobacco research: a short report.
Tob Control
January 2025
Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA.
Background: Social media influencers who promote e-cigarettes on Instagram or TikTok for tobacco brands use marketing tactics to increase the appeal of their promotional content, for example, depicting e-cigarettes alongside healthy lifestyle or entertainment imagery that could decrease youths' risk perceptions of e-cigarettes. Monitoring the prevalence of such content on social media using computer vision and generative AI (artificial intelligence) can provide valuable data for tobacco regulatory science (TRS).
Methods: We selected 102 Instagram and TikTok videos posted by micro-influencers in 2021-2024 who promoted e-cigarettes alongside posts featuring four themes: cannabis, entertainment, fashion or healthy lifestyle.
Destruction of perfluorooctanoic acid (PFOA) and perfluorooctadecanoic acid (PFOcDA) by incineration: Analysis of the by-products and their characteristics.
Chemosphere
January 2025
Graduate School of Science and Technology, Ryukoku University, 1-5 Yokotani, Seta Oe-cho, Otsu, Shiga 520-2194, Otsu, Japan. Electronic address:
Per- and polyfluoroalkyl substances (PFAS), which are considered an international problem due to their persistence in the environment, need to be properly treated in the end. In the destruction method by incineration, basic data are required to quantify the destruction characteristics of the target substance and the temperature-dependent behavior of its by-products. In this study, we conducted incineration tests targeting perfluorooctanoic acid (PFOA) and perfluorooctadecanoic acid (PFOcDA).
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