In the experiment (on the basis of values of antipyrine (phenazone) pharmacokinetics parameter), biotransformation activity of calves liver during a year was determined. The experiment was carried out on calves aged 28-30 days. Volume of distribution (Vd), half-life (t0.5) and metabolic clearance (CA) of antipyrine were from month to month determined. Not significant changes between values of Vd, t0.5 and CA in several months were observed. Results of experiment indicated that calves' liver is characterized by the relatively stabile biotransformational activity during the whole year.
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