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AMPK Activation Downregulates TXNIP, Rab5, and Rab7 Within Minutes, Thereby Inhibiting the Endocytosis-Mediated Entry of Human Pathogenic Viruses.
Cells
February 2025
Institute of Virology and Immunobiology, University of Würzburg, Versbacher Str. 7, 97078 Würzburg, Germany.
Cellular metabolism must adapt rapidly to environmental alterations and adjust nutrient uptake. Low glucose availability activates the AMP-dependent kinase (AMPK) pathway. We demonstrate that activation of AMPK or the downstream Unc-51-like autophagy-activating kinase (ULK1) inhibits receptor-mediated endocytosis.
View Article and Find Full Text PDFTick-borne encephalitis virus seroprevalence and infection incidence in Switzerland, 2020-2021.
Sci Rep
March 2025
Microbiologie, ADMED Analyses et Diagnostics Médicaux, La Chaux-de-Fonds, Switzerland.
Tick-borne encephalitis virus (TBEV) infection can manifest as disease of variable severity, ranging from subclinical infection to severe disease with neurological involvement and potentially fatal outcome. Although TBE is recognized as a major public health problem in Europe, the true burden of disease is potentially underestimated. Here, we investigated TBEV-specific antibody prevalence, infection incidence, and seroreversion and antibody decline rates in a prospective Swiss healthcare worker (HCW) cohort.
View Article and Find Full Text PDFTick-borne pathogens in ticks removed from humans in Northern Italy, 2018-2023.
Acta Trop
March 2025
Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER), Sede Territoriale di, Pavia, Italia. Electronic address:
The rising prevalence and transmission of tick-borne pathogens (TBPs) represent a significant public health issue all over the world, including in Italy. The region of Lombardy, in Northern Italy, is particularly endemic for TBPs. While evidence indicates a high exposure risk to infected ticks, there is a lack of data on ticks collected from humans.
View Article and Find Full Text PDFBackground: Alkhumra hemorrhagic fever virus is a newly discovered tick-borne flavivirus that was first identified in 1994 - 1995 in the Alkhumra district of Jeddah, Kingdom of Saudi Arabia. AHFV was detected in a butcher who developed severe hemorrhagic fever. Since then, a total of 604 confirmed cases have been reported in KSA between 1995 - 2020.
View Article and Find Full Text PDFClimate change's impact on the nervous system: A review study.
Health Promot Perspect
December 2024
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Background: Global warming is caused by increased carbon dioxide and other industrial gases, which shift the climate of human habitat and environment, impacting human health globally. In this review, we tried to overview the current knowledge of climate change's impact on neurological disease.
Methods: A comprehensive search on PubMed, Web of Science (WOS), and Scopus was conducted to find the relevant original studies.
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