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Van Wyk-Grumbach Syndrome with bilateral inguinal hernia: A case report.
Int J Surg Case Rep
January 2025
Institute of Oncology, Sri Ramakrishna Hospital, Coimbatore, India.
Introduction: Van Wyk-Grumbach Syndrome (VWGS) is a rare pediatric endocrinological disorder characterized by hypothyroidism, delayed bone age, enlarged multicystic ovaries, and precocious puberty. It results from prolonged hypothyroidism, affecting the hypothalamic-pituitary-gonadal axis. This report describes a 7-year-old girl presenting with vaginal bleeding and abdominal pain, leading to a diagnosis of VWGS with bilateral inguinal hernia and requiring surgical intervention.
View Article and Find Full Text PDFGut microbiota, metabolites, and cytokines in relation to the risk of prostate cancer in the Asian population.
Front Oncol
January 2025
Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Purpose: Studies have shown that gut microbiota is involved in the tumorigenesis and development of prostate cancer. We aimed to perform a comprehensive analysis of causal associations of gut microbiota, metabolites, and cytokines with prostate cancer in the Asian population.
Patients And Methods: Genome-wide association study (GWAS) summary datasets were collected from the public databases.
Telitacicept for systemic lupus erythematosus with post‑surgical papillary thyroid carcinoma: A case report.
Biomed Rep
March 2025
Department of Rheumatology and Immunology, People's Hospital of Longhua, Shenzhen, Guangdong 518109, P.R. China.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex etiology primarily linked to abnormalities in B lymphocytes within the human body, resulting in the production of numerous pathogenic autoantibodies. Telitacicept is a relatively novel humanized, recombinant transmembrane activator, calcium modulator and cyclophilin ligand interactor fused with the Fc portion (TACI-Fc). It works by competitively inhibiting the TACI site, neutralizing the activity of B-cell lymphocyte stimulator and A proliferation-inducing ligand.
View Article and Find Full Text PDFThe Role of Neck Ultrasonography and Nuclear Imaging in the Diagnosis of Congenital Hypothyroidism.
Indian J Endocrinol Metab
December 2024
Department of Endocrinology, Madurai Medical College and Govt. Rajaji Hospital, Madurai, Tamil Nadu, India.
Introduction: Congenital hypothyroidism (CH) is the most common preventable cause of mental retardation, and the two important causes of CH are thyroid dysgenesis and dyshormonogenesis. Thyroid imaging is an integral part of identifying the specific aetiology of CH. We aimed to study the aetiological profile of CH and compare the imaging findings of ultrasonography (USG) and nuclear scintigraphy.
View Article and Find Full Text PDFElucidating the Prognostic Role of and the Activation Status of the Downstream MAPK Pathway in PTC: A Study from a Tertiary Centre in India.
Indian J Endocrinol Metab
December 2024
Department of Surgery, All India Institute of Medical Sciences, New Delhi, India.
Introduction: Papillary thyroid carcinoma (PTC) has an excellent prognosis, but few cases are treatment-resistant. To check the applicability of combined and MEK-targeted therapy, the current study correlated with the MAPK pathway activation status in a cohort of PTCs. The prognostic relevance of and the usability of immunohistochemistry (IHC) for detecting the mutation were also assessed.
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