AI Article Synopsis
- The study aimed to assess how effective and safe itraconazole is for treating P. marneffei infections in patients.
- Ten previously untreated patients received a specific regimen of oral itraconazole, resulting in clinical improvement for most, although two patients died during treatment.
- While itraconazole was effective initially, relapse of the infection occurred in some patients, indicating the need for long-term treatment options.
Article Abstract
Objectives: to evaluate the efficacy and safety of itraconazole in treating P. marneffei infection.
Methods: Ten patients with previously untreated P. marneffei infection were given oral itraconazole at a dose of 200 mg twice a day for 2 months, followed by a dose of 100 mg once a day for 1 month. Efficacy was determined by the clinical and microbiological cure.
Results: All but one patient were seropositive for human immunodeficiency virus (HIV). Two patients died during therapy. Clinical improvement was evident in 8 patients. In 7 of these, the mean duration for becoming culture negative was 57 days. Five patients presented with relapse of P. marneffei infection within four months after completion of treatment.
Conclusions: Itraconazole was shown to be effective in the initial treatment of P. marneffei infection. Relapse after treatment is common and long-term suppressive therapy is recommended.
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