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Anemia and Mineral Bone Disorder in Kidney Disease Patients: The Role of FGF-23 and Other Related Factors.
Int J Mol Sci
November 2024
Department of Health Sciences, "Magna Graecia" University, I88100 Catanzaro, Italy.
Anemia and mineral and bone disorder (MBD) are significant complications of chronic kidney disease (CKD). The erythropoietin (Epo) pathway plays a key role in both of these processes in CKD. Another molecule that plays an important role in CKD-MBD is fibroblast growth factor (FGF)-23, whose main role is to maintain serum phosphate levels in the normal range, acting via its co-receptor Klotho; however, its activity may also be related to anemia and inflammation.
View Article and Find Full Text PDFHypovitaminosis D in university workers in Southern Ecuador: interactions between gender and lifestyle.
Front Nutr
September 2024
Clinical Laboratory Service, Juan Manuel Márquez Pediatric Teaching Hospital, Havana, Cuba.
Background: Hypovitaminosis D may be common in tropical countries and is linked to disorders of phospho-calcium metabolism, rickets, muscle pain, immune system deficiencies, and increased susceptibility to microbial infections.
Objective: To assess the prevalence of hypovitaminosis D in apparently healthy university workers in Loja, Ecuador.
Methods: A cross-sectional study was completed in a private Ecuadorian university from May 2023 to September 2023, involving 440 participants.
FGF23 and Cell Stress in SaOS-2 Cells-A Model Reflecting X-Linked Hypophosphatemia Dynamics.
Cells
September 2024
Department of Cytology, Institute of Anatomy, Ruhr-University Bochum, D-44801 Bochum, Germany.
Article Synopsis
- The study explores how overexpressing FGF23 affects SaOS-2 cells, particularly regarding stress responses and morphology, and its relation to skeletal disorders like X-linked hypophosphatemia (XLH).
- Researchers utilized transmission electron microscopy and protein analysis to observe changes in the rough endoplasmic reticulum (rER) and mitochondria of these cells, noting significant alterations such as enlargement and increased contact zones.
- The findings indicate higher rates of apoptosis and activation of pathways related to cellular stress, suggesting that FGF23 overexpression plays a critical role in how cells manage protein synthesis demands and stress, paving the way for potential therapeutic strategies for related diseases.
Vitamin D Status and Treatment in ESKD: Links to Improved CKD-MBD Laboratory Parameters in a Real-World Setting.
Am J Nephrol
December 2024
Department of Medicine, Queen's University, Kingston, Ontario, Canada.
Article Synopsis
- Vitamin D insufficiency is prevalent among hemodialysis patients, but there's a lack of clear guidelines for its monitoring and treatment.
- A study of 697 patients found that increasing levels of 25(OH)D3 were linked to reduced levels of parathyroid hormone (PTH) and phosphate, especially when levels were between 25 and 75 nmol/L.
- The study concluded that treating vitamin D in these patients appears safe and correlated with lower PTH, but more research is needed to see if these biochemical improvements lead to better clinical outcomes.
Coactivator-independent vitamin D receptor signaling causes severe rickets in mice, that is not prevented by a diet high in calcium, phosphate, and lactose.
Bone Res
August 2024
Department of Chronic diseases and metabolism, Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium.
Article Synopsis
- The vitamin D receptor (VDR) is essential for regulating bone health, and its activation typically involves binding to vitamin D and the recruitment of coactivators for gene transcription.
- This study used mice with a deletion of the VDR-AF2 domain to explore how VDR functions without coactivators, revealing that these mutant mice had significant bone issues compared to regular knockout mice.
- Findings indicated that while a rescue diet could improve some bone problems in one group of mutant mice, coactivator-independent VDR functions likely play a more vital role in organs other than bones, affecting overall mineral homeostasis.
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