The authors present the results of medical treatment in patients with head and neck cylindromas hospitalized in the Department of Otolaryngology. The Zeromski Hospital in Kraków, within the period 1961 to 1988.
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Potentially actionable molecular alterations in particular related to poor oncologic outcomes in salivary gland carcinomas.
BMC Cancer
January 2025
Department of Tumor Biology and Genetics, Medical University of Warsaw, Warsaw, Poland.
Aim: The study was designed to evaluate molecular alterations, relevant to the prognosis and personalized therapy of salivary gland cancers (SGCs).
Materials And Methods: DNA was extracted from archival tissue of 40 patients with various SGCs subtypes. A targeted next-generation sequencing (NGS) panel was used for the identification of small-scale mutations, focal and chromosomal arm-level copy number changes.
Article Synopsis
- Adenoid cystic carcinomas (AdCC) of salivary gland origin are primarily defined by the presence of specific gene fusions, notably MYB::NFIB and MYBL1::NFIB, with sinonasal AdCC being particularly aggressive and lacking effective treatments.
- Researchers conducted an extensive analysis of 88 sinonasal AdCC cases using various techniques like NGS and FISH to identify gene fusions and mutations, finding that the majority harbored canonical fusions while some had noncanonical ones, with a few tumors showing no fusions at all.
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Retraction of: CCNA2 and KIF23 are molecular targets for the prognosis of adenoid cystic carcinoma.
Aging (Albany NY)
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Department of Otolaryngology, Head and Neck Surgery, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050030, P.R. China.
A review of submandibular gland extirpation in an Australian quaternary referral centre: aetiologies and trends over 35 years.
ANZ J Surg
December 2024
Department of Head and Neck Surgery, Chris O'Brien Lifehouse, Sydney, New South Wales, Australia.
Background: Submandibular gland pathology is common but rarely reported. This study was performed to evaluate demographic, pathological, and survival outcomes associated with submandibular gland extirpation.
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Revealing the Enigma: A Deep Dive Into Submandibular Adenoid Cystic Carcinoma and Its Management.
Cureus
November 2024
Radiation Oncology, Faculty of Medicine and Pharmacy - Mohammed First University, oujda, MAR.
Adenoid cystic carcinoma (ACC) of the submandibular gland is a rare and highly aggressive malignancy, distinguished by its tendency for perineural invasion and distant metastasis, particularly to the lungs and bones. The management of ACC is challenging due to its biological variability and the absence of specific randomized controlled trials to guide treatment. This report aims to encapsulate the clinical features, histological profile, diagnostic workup, and management options for submandibular gland ACC, with an emphasis on recent advancements in understanding and treatment.
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