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Challenges in the Management of a Difficult-to-Treat Patient With Hairy Cell Leukemia: A Case Report.
Cureus
December 2024
Family Medicine, Augusta University Medical College of Georgia, Chatsworth, USA.
Hairy cell leukemia (HCL) is a rare, chronic B-cell malignancy with an indolent course that typically responds well to purine nucleoside analogs, such as cladribine. We present the case of a 74-year-old woman with nearly three decades of recurrent HCL, marked by multiple relapses and significant toxicities to various treatments, including purine analogs, BRAF inhibitors, BTK inhibitors, a cytoreductive agent, and the monoclonal antibody rituximab. Despite severe allergic reactions and intolerances to standard therapies, the patient achieved multiple remissions.
View Article and Find Full Text PDFPickering Syndrome Manifesting as Recurrent Pulmonary Edema in an Older Woman With Renal Artery Stenosis.
JACC Case Rep
January 2025
Department of Cardiology, Málaga Regional University Hospital, Málaga, Spain.
Pickering syndrome, characterized by recurrent episodes of flash pulmonary edema (FPE) and renal impairment, is associated with renal artery stenosis (RAS). This case highlights its manifestation and management in an older adult patient. An 86-year-old woman with hypertension, chronic kidney disease, and a single functioning kidney presented with recurrent FPE episodes.
View Article and Find Full Text PDFManagement of Idiopathic Granulomatous Mastitis: Effectiveness of a Steroid-Free Regimen Using -A Single-Institution Experience.
Breast J
January 2025
Department of Surgical Oncology, Breast Services, Tata Memorial Centre and Homi Bhabha National Institute, Mumbai, India.
Idiopathic granulomatous mastitis (IGM) is a benign, chronic inflammatory disease with no effective treatment and high relapse rate. The pathophysiology is poorly understood. Tinosporin, an immunomodulator obtained from , is known to be useful in treating immune-mediated diseases.
View Article and Find Full Text PDFBehcet syndrome: A rare cause of recurrent genital ulceration.
Indian J Sex Transm Dis AIDS
December 2024
Department of Dermatology, Venereology and Leprosy, Government Medical College and S.S.G. Hospital, Vadodara, Gujarat, India.
Behcet syndrome (BS) is a chronic relapsing multisystem vasculitis with skin findings with an important contribution of genetics. Here, we present a case of a 16-year-old male with a complaint of recurrent genital, and oral ulceration with skin lesions and a history of recurrent thrombophlebitis at the sites of venepuncture. There were no systemic manifestations.
View Article and Find Full Text PDFMultifaceted Action of 1,8-Cineole in Antibacterial and Anti-inflammatory Treatment of Respiratory Tract Diseases.
Otolaryngol Pol
January 2025
"P.U.M.A." Platform for Unique Models Application, Department of Pharmaceutical Microbiology and Parasitology, Wroclaw Medical University, Wroclaw, Poland.
1,8-cineole, renowned for its versatile therapeutic properties, has long been utilized in the treatment of respiratory system disorders. Its potential for oral administration offers a new dimension as an effective systemic therapy with anti-inflammatory and antibacterial effects. Maintaining stable levels of the compound in the body enhances treatment efficacy and reduces the risk of recurrence.
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