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Identification of Bioactive Compounds from the Roots of and Their In Silico and In Vitro AMPK Activation Potential.
Molecules
December 2024
Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 03760, Republic of Korea.
Libosch., which belongs to the Orobanchaceae family, is a perennial herb found in China, Japan, and Korea. In traditional medicine, it is used to cool the body, improve water metabolism in the kidney, and provide protection from metabolic diseases such as type 2 diabetes mellitus (T2DM) and obesity.
View Article and Find Full Text PDFFast and Efficient Screening and Separation Based on AUF-MS Combined With Molecular Docking Technology and Network Pharmacology Method for Potential Xanthine Oxidase Inhibitors From Pinelliae Rhizoma Praeparatum.
Phytochem Anal
December 2024
Central Laboratory, Changchun Normal University, Changchun, China.
Introduction: Studies show that Pinelliae Rhizoma Praeparatum (PRP) has some pharmacological effects in enhancing immunity and against gout.
Objectives: A mathematical model was created for extraction process optimization, analysis and identification, activity screening, and isolation and purification; moreover, the mechanism of action was studied.
Methods: First, the extraction of PRP was investigated using the gray wolf optimization mathematical regression model; the extraction variables were optimized to maximize the yield.
[A new flavan-3-ol from Sargentodoxae Caulis].
Zhongguo Zhong Yao Za Zhi
October 2024
School of Pharmacy, Shandong University of Traditional Chinese Medicine Ji'nan 250300, China Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences) Ji'nan 250014, China Shandong Provincial Key Laboratory of Natural Active Pharmaceutical Constituents Research in Universities, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences) Ji'nan 250014, China.
Sargentodoxae Caulis was extracted with 80% ethanol and separated by macroporous resin, MCI, and ODS column chromatography and semi-preparative high performance liquid chromatography. The structures of the compounds were identified based on the NMR and MS data. A total of 19 compounds were identified as parabaroside D(1),(R)-2-(3,4-dihydroxyphenyl)-2-hydroxyethyl-O-β-D-glucopyranoside(2),(S)-2-(3,4-dihydroxyphenyl)-2-hydroxyethyl-O-β-D-glucopyranoside(3), protocatechin-3-O-β-D-glucoside(4), p-hydroxybenzoate-β-D-glucopyranoside(5), gentisic-5-O-β-D-glucopyranoside(6), vanillic acid 4-O-β-D-glucoside(7), syringic acid glucoside(8), uracil(9), uridine(10), neochlorogenic acid(11), chlorogenic acid(12), cryptochlorogenic acid(13), 3,4-dihydroxyphenylethanol glucoside(14), cuneataside A(15), cuneataside C(16), 4-hydroxy-3-methoxyacetophenone-4-O-β-D-apiose-(1→6)-β-D-glucopyranoside(17), proanthocyanidin B2(18), and baimantuoluoamide B(19).
View Article and Find Full Text PDFOxidative Deformylation of the Predominant DNA Lesion 5-Formyl-2'-deoxyuridine.
Chem Res Toxicol
December 2024
Department of Medical Imaging and Radiation Sciences, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, Québec J1H 5N4, Canada.
Radical oxidation of DNA gives rise to potentially deleterious lesions such as strand breaks and various nucleobase modifications including 5-formyl-2'-deoxyuridine (5-fo-dU), a prevalent product derived from the oxidation of the C5-methyl group of thymidine. The present study investigates the unusual transformation of 5-fo-dU into 5-hydroxy-2'-deoxyuridine (5-oh-dU) and 5,6-dihydroxy-5,6-dihydro-2'-deoxuridine (gly-dU), two products typically associated with the oxidation of 2'-deoxycytidine. Detailed mechanistic analyses reveal that hydrogen peroxide, either generated as a byproduct of ascorbate autoxidation or added exogenously, mediates the formation of these oxidatively induced C5-dealkylated products.
View Article and Find Full Text PDFCrosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance.
Mol Oncol
November 2024
Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, China.
Gut microbiota has a proven link with the development and treatment of cancer. However, the causality between gut microbiota and cancer development is still unknown and deserves exploration. In this study, we aimed to explore the alterations in gut microbiota in murine tumor models and the crosstalk between the tumor and the gut microbiota.
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