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Unveiling the role of OsSAP17: Enhancing plant resistance to drought and salt.
Plant Physiol Biochem
December 2024
College of Ecology and Environment, Chengdu University of Technology, Sichuan, 610059, China; Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, Lanzhou University, Lanzhou, 730000, China; Key Laboratory of Monitoring for Heavy Metal Pollutants, Ministry of Ecology and Environment, Hunan, 410019, China. Electronic address:
With the intensification of climate change coupled with the inadequate agricultural management in certain regions, plants face numerous challenges due to various abiotic stresses. Stress associated proteins (SAPs) are essential functional genes in plants for coping with stress. This research provides a functional analysis of OsSAP17, a protein belonging to the SAP family in rice.
View Article and Find Full Text PDFBacillus subtilis inoculated in organic compost could improve the root architecture and physiology of soybean under water deficit.
Plant Physiol Biochem
January 2025
Universidade do Oeste Paulista (UNOESTE), Presidente Prudente, SP, Brazil.
Bacillus subtilis is known to promote root growth and improve plant physiology, while organic compost enhances soil water retention. This study explored the combined effect of inoculating B. subtilis in organic compost on soybean growth under water deficit.
View Article and Find Full Text PDFAssociations between 25-hydroxyvitamin D/calcium/alkaline phosphatase levels and the risk of developing kidney stones: Results from NHANES (2013-2018)-based and Mendelian randomization studies.
Medicine (Baltimore)
January 2025
Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
This study explores the relationship between 25-hydroxyvitamin D/calcium/alkaline phosphatase (ALP) levels and kidney stone development via cross-sectional and Mendelian randomization (MR) analyses. We used data from the National Health and Nutrition Examination Survey (NHANES) 2013 to 2018 to explore the associations of 25(OH)D metabolite, calcium, and ALP levels with kidney stone development, LDSC analysis to determine the associations between their genetically predicted levels and kidney stone development, and MR analysis to determine the causality of those relationship via genome-wide association studies (GWASs). The cross-sectional study revealed a relationship between ALP levels and kidney stone development (Model 1: OR = 1.
View Article and Find Full Text PDFRecent advances in osteoarthritis research: A review of treatment strategies, mechanistic insights, and acupuncture.
Medicine (Baltimore)
January 2025
The Third Affiliated Hospital of Xinxiang Medical University, Henan, China.
Osteoarthritis (OA) is a chronic joint condition affecting millions worldwide, characterized by the gradual degeneration of joint cartilage, leading to pain, stiffness, and functional impairment. Although the pathogenesis of OA is not fully understood, the roles of inflammation, metabolic dysregulation, and biomechanical stress are increasingly recognized. Current treatments, including pharmacotherapy, physical therapy, and surgical interventions, aim to alleviate symptoms and improve quality of life, yet they face limitations and challenges.
View Article and Find Full Text PDFAssociations of cathepsins with pulmonary arterial hypertension mediated by circulating metabolites: A Mendelian randomization study.
Medicine (Baltimore)
January 2025
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
The correlation between cathepsins and pulmonary arterial hypertension (PAH) is well-established, but the causative link between them remains uncertain. This study aimed to explore the causal role of circulating metabolites mediating cathepsins in PAH using Mendelian randomization (MR). A 2-sample 2-step MR method was used to identify causal relationship between cathepsins and PAH; causal relationship between circulating metabolites and PAH; and mediated effects of these circulating metabolites.
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