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A method for rapid mouse siderocyte enrichment.
Exp Hematol
December 2005
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, 92037, USA.
Objective: Iron overload is a key contributor to the pathogenesis of multiple disorders including the sideroblastic anemias. The specific iron compounds present in tissues or cells that are the target of iron deposition remain poorly understood, but there is evidence that some forms are magnetically active. We have developed a simple and specific method to purify iron-overloaded red blood cells using magnetic affinity columns.
View Article and Find Full Text PDFSOD2-deficiency anemia: protein oxidation and altered protein expression reveal targets of damage, stress response, and antioxidant responsiveness.
Blood
October 2004
The Scripps Research Institute, Department of Molecular and Experimental Medicine, MEM131, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA.
SOD2 is an antioxidant protein that protects cells against mitochondrial superoxide. Hematopoietic stem cells (HSCs) lacking SOD2 are capable of rescuing lethally irradiated hosts, but reconstituted animals display a persistent hemolytic anemia characterized by increased oxidative damage to red cells, with morphologic similarity to human "sideroblastic" anemia. We report further characterization of this novel SOD2-deficiency anemia.
View Article and Find Full Text PDFMyelodysplastic syndrome with sideroblastic differentiation in a dog.
Vet Clin Pathol
January 1999
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
A dog with myelodysplastic syndrome had microcytic hypochromic anemia, with siderocytes, poikilocytosis, hypersegmented neutrophils and giant platelets in peripheral blood. In bone marrow, the erythroid series showed immaturity, asynchronous maturation and sideroblasts. Dysgranulopoiesis and dysthrombopoiesis also were present, and hemosiderin was increased.
View Article and Find Full Text PDFHypersegmented megakaryocytes and megakaryocytes with multiple separate nuclei in dogs treated with PNU-100592, an oxazolidinone antibiotic.
Toxicol Pathol
October 1997
Worldwide Toxicology, Pharmacia & Upjohn, Inc., Kalamazoo, Michigan 49001, USA.
Megakaryocytes in normal dogs have a variety of nuclear forms. The most common variations are a single large multilobed nucleus or a segmented nucleus consisting of irregular nuclear lobes joined by strands of chromatin. Exaggerated segmentation (hypersegmentation) of the nucleus occurs in a small number of megakaryocytes.
View Article and Find Full Text PDFDyserythropoeisis, sideroblasts/siderocytes and hemoglobin crystallization in a dog.
Vet Clin Pathol
January 1987
Departments of Veterinary Pathology and Veterinary Clinical Studies, University of Sydney, N.S.W. Australia.
Dyserythropoiesis characterized by enhanced intramedullary destruction, pathologic sideroblasts and siderocytes, and hemoglobin crystallization was detected in a female Cocker Spaniel presented for poor exercise tolerance. Examination of peripheral blood revealed intraerythrocytic crystals, granulation of erythrocytes, nucleated erythroid cells, reticulocytosis and marked variation in erythrocyte morphology in the absence of anemia. Bone marrow examination revealed sideroblasts, a low M:E ratio and evidence of enhanced intramedullary destruction of erythroid cells.
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