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Evaluation of agonistic and antagonistic effects of unprenylated and prenylated flavonoids on estrogen receptor-α.
Chem Biol Interact
January 2025
Department of Food Science and Biotechnology, Andong National University, Andong, 36729, Republic of Korea. Electronic address:
Prenylation, which involves the addition of hydrophobic molecules, is considered to enhance the bioavailability and biological activity of flavonoids. However, the effect of prenylation on the estrogenic activity of flavonoids with different structures remains unclear. This study evaluated the estrogen receptor-α (ER-α) agonistic and antagonistic activities of estrogenic flavonoids in both unprenylated and prenylated forms using OECD standardized in vitro ER-α transactivation assay and in vivo uterine hypertrophy assay.
View Article and Find Full Text PDFResearch Advances in Adenomyosis-Related Signaling Pathways and Promising Targets.
Biomolecules
November 2024
Department of Gynecology, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730000, China.
Adenomyosis is a benign gynecological condition characterized by the proliferation of the endometrial stroma and glands into the myometrium, uterine volume enlargement, and peripheral smooth muscle hypertrophy. The typical clinical symptoms include chronic pelvic pain, abnormal uterine bleeding, and subfertility, all of which significantly impact quality of life. There are no effective prevention or treatment strategies for adenomyosis, partly due to a limited understanding of the pathological mechanisms underlying the initiation and progression of the disease.
View Article and Find Full Text PDFBisphenol A-induced polycystic ovary syndrome (PCOS) with hormonal and metabolic implications in rats.
Reprod Toxicol
January 2025
Molecular Toxicology Laboratory, Department of Medical Elementology and Toxicology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi 110062, India. Electronic address:
There is a rising incidence of polycystic ovary syndrome (PCOS) cases worldwide in women of reproductive age due to environmental factors. We evaluated the effect of an environmental estrogen, bisphenol A (BPA) for its reprotoxicity regarding the induction of PCOS in rats and also assessed its hormonal and metabolic implications. There was 66.
View Article and Find Full Text PDFImpacts of low birthweight on kidney development and intergenerational growth of the offspring.
iScience
November 2024
Division of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai 980-8578, Japan.
Low birthweight (LBW) increases the risk of adult-onset diseases, including kidney diseases, with intergenerational consequences; however, the underlying mechanisms and effective interventions are unclear. To examine the cross-generational effects of LBW, we established an LBW mouse model through reduced uterine perfusion pressure (RUPP) and investigated the therapeutic potential of tadalafil, a phosphodiesterase 5 inhibitor, on LBW-associated consequences. RUPP-pups (R1) had lower fetal and birth weights, delayed renal development, and fewer glomeruli than Sham-pups.
View Article and Find Full Text PDFEffects of maternal preconception high-fat diet on the fertility of dams and on the somatic parameters and reflex ontogeny of their male offspring.
Physiol Behav
January 2025
Laboratory of Experimental Nutrition, Department of Nutrition, Health Sciences Centre, Federal University of Paraíba (UFPB), João Pessoa, Paraíba, Brazil; Post Graduate Program in Nutrition Sciences, Health Sciences Centre, Federal University of Paraíba (UFPB), João Pessoa, Paraíba, Brazil. Electronic address:
Background: Female consumption of a high-fat diet (HFD) may cause fertility issues and affects offspring development.
Objective: Evaluate the acute maternal preconception intake of a HFD on the fertility and reproduction parameters of breeding females; and on the somatic parameters and reflex ontogeny of male offspring.
Methods: Twenty-four rats were randomized into control (PC; n=12) and high-fat diet group (PHF; n=12) that consumed their respective diets during the 23-day preconception period.
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