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Fetal Tetra-Amelia Birth: A Case Report.
Case Rep Obstet Gynecol
December 2024
Department of Obstetrics and Gynecology, Jimma University School of Medicine, Jimma, Ethiopia.
Fetal limb anomaly presentation varies greatly. It can present as amelia (complete absence of skeletal part of one or more limb), meromelia (partial absence of skeletal part of one or more limb), phocomelia (only rudimentary limb formed), and minor limb disorders like polydactyly. The complete absence of the four fetal limbs is extremely rare.
View Article and Find Full Text PDFEnzymatically enhanced ultrastructure expansion microscopy unlocks expansion of cysts.
mSphere
September 2024
Institute of Immunology and Infection Research, School of Biological Sciences, Ashworth laboratories, University of Edinburgh, Edinburgh, United Kingdom.
Unlabelled: Expansion microscopy (ExM) is an innovative approach to achieve super-resolution images without using super-resolution microscopes, based on the physical expansion of the sample. The advent of ExM has unlocked the detail of super-resolution images for a broader scientific circle, lowering the cost and entry skill requirements for the field. One of its branches, ultrastructure expansion microscopy (U-ExM), has become popular among research groups studying apicomplexan parasites, including the acute stage of infection.
View Article and Find Full Text PDFIdentification of hub genes and key modules in laryngeal squamous cell carcinoma.
Transl Cancer Res
July 2024
Department of Otolaryngology Head and Neck Surgery, Civil Aviation General Hospital (Peking University Civil Aviation School of Clinical Medicine), Beijing, China.
Background: Laryngeal squamous cell carcinoma (LSCC) is the prominent cancer in head and neck, which greatly affects life quality of patients. The pathogenesis of LSCC is not clear. Presently, the LSCC treatments include chemotherapy, surgery and radiotherapy; however, these methods have poor efficacy in patients with recurrent and persistent cancer.
View Article and Find Full Text PDFA combination of GRA3, GRA6 and GRA7 peptides offer a useful tool for serotyping type II and III infections in sheep and pigs.
Front Cell Infect Microbiol
May 2024
SALUVET group, Faculty of Veterinary Sciences, Animal Health Department, Complutense University of Madrid, Madrid, Spain.
The clinical consequences of toxoplasmosis are greatly dependent on the strain causing the infection. To better understand its epidemiology and design appropriate control strategies, it is important to determine the strain present in infected animals. Serotyping methods are based on the detection of antibodies that react against segments of antigenic proteins presenting strain-specific polymorphic variations, offering a cost-effective, sensitive, and non-invasive alternative to genotyping techniques.
View Article and Find Full Text PDFProperties and predicted functions of large genes and proteins of apicomplexan parasites.
NAR Genom Bioinform
June 2024
Department of Internal Medicine, Section of Infectious Diseases, Department of Microbial Pathogenesis and Department of Pathology, Yale School of Medicine, New Haven, CT, 06520 USA.
Evolutionary constraints greatly favor compact genomes that efficiently encode proteins. However, several eukaryotic organisms, including apicomplexan parasites such as , and , the causative agents of toxoplasmosis, malaria and babesiosis, respectively, encode very large proteins, exceeding 20 times their average protein size. Although these large proteins represent <1% of the total protein pool and are generally expressed at low levels, their persistence throughout evolution raises important questions about their functions and possible evolutionary pressures to maintain them.
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