This article studies the adaptative mechanisms of the immune system of servicemen in the Aral Sea region in response to the influence of unfavourable xenobiotic factors of the environment. The greatest homeostatic shifts were disclosed in servicemen of the 2nd and the 4th periods of service (6 months and 2 years of active duty correspondingly). Precisely these periods of selective service have the highest infectivity index. It is recommended to measure the volume of catabolic products of cell receptors (P-proteins) in order to obtain an integral index which could characterize the adaptative mechanisms of the immune system during the screening of servicemen in the conditions of unfavourable environment.

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