The effects of peripherally administered thyroid hormone (TH; 500 micrograms/kg; i.p.; q.d.) on the relative abundances of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) RNA were determined by rtPCR in the cortex and hippocampus of young adult rats. Corresponding changes in choline acetyltransferase (ChAT) activity were measured since NGF and BDNF have been shown to enhance the expression of this marker enzyme of central cholinergic pathways. Abundance levels of NGF and NT-3, relative to cyclophilin (cycl), were increased significantly (+50%, P < 0.05) in the hippocampus following TH treatment. Despite enhanced abundance of NGF in the hippocampus, ChAT activity was unchanged, whereas ChAT activity was modestly increased by 28% in the cortex without corresponding changes in NGF, NT-3 or BDNF. These results demonstrate that TH administration is capable of inducing the accumulation of NT-3, in addition to NGF but that the induction levels of RNA cannot be directly correlated with responsivity of the cholinergic system as measured by ChAT activity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0169-328x(92)90231-y | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Advancements in AI Medical Education: Assessing ChatGPT's Performance on USMLE-Style Questions Across Topics and Difficulty Levels.
Cureus
December 2024
Medical Education, University of South Florida Morsani College of Medicine, Tampa, USA.
Background AI language models have been shown to achieve a passing score on certain imageless diagnostic tests of the USMLE. However, they have failed certain specialty-specific examinations. This suggests there may be a difference in AI ability by medical topic or question difficulty.
View Article and Find Full Text PDFEvaluating the Accuracy of ChatGPT in the Japanese Board-Certified Physiatrist Examination.
Cureus
December 2024
Department of Rehabilitation Medicine, Mie University Graduate School of Medicine, Tsu, JPN.
Background Generative artificial intelligence (AI), such as Chat Generative Pre-trained Transformer (ChatGPT), has shown potential in various medical applications, including answering licensing examination questions. However, its performance in rehabilitation medicine remains underexplored. This study aimed to evaluate the accuracy of ChatGPT4o in answering questions from the Japanese Board-Certified Physiatrist Examination and assess its potential as an educational and clinical support tool.
View Article and Find Full Text PDFImproving Outcomes and Quality of Life for Patients With Hand and Foot Eczema: Randomized Study of a Patient-Centered Monitoring App.
J Med Internet Res
January 2025
Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.
Background: Hand and foot eczema is a frequent chronic dermatological condition. The persistent itching, pain, and blistering can impair hand and foot function, leading to difficulties in performing tasks requiring fine motor skills. In addition, the impact on the quality of life for affected patients is significant, as the symptoms can be extremely uncomfortable and disruptive to daily activities.
View Article and Find Full Text PDFEffects of group communication norms on daily steps in a team-based financial incentive mobile phone intervention in Shanghai, China.
Int J Behav Nutr Phys Act
January 2025
Prevention Research Collaboration, Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, 2006, Australia.
Background: Mobile technology offers great potential for physical activity promotion, especially by facilitating online communication, however, the impact of group communication norms on intervention effectiveness remains unclear. This study aimed to evaluate the effect on daily steps of a team-based social norms-related intervention using a mobile application.
Methods: The 13-week quasi-experimental study was conducted in Shanghai, China, from September to November 2019, involving 2,985 employees from 32 worksites.
Esmolol upregulates the α7 nAChR/STAT3/NF-κB pathway by decreasing the ubiquitin and increasing the ChATCD4 T lymphocyte to alleviate inflammation in septic cardiomyopathy.
Int Immunopharmacol
January 2025
Department of Critical Care Medicine, the Affiliated Hospital of Qingdao University, Qingdao 266000 Shandong, China. Electronic address:
Esmolol has been demonstrated to mitigate inflammation damage and T lymphocyte apoptosis in septic cardiomyopathy. It has been established that the activation of α7 nicotinic acetylcholine receptor (nAChR) by cluster of differentiation 4(CD4) T lymphocytes expressing choline acetyltransferase (ChAT) can prevent excessive inflammation and reduce splenocyte apoptosis in septic cardiomyopathy. Given the similar anti-inflammatory effects, we hypothesized that esmolol might be associated with α7 nAChR and thereby exert its cardioprotective functions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!