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Defective Slc7a7 transport reduces erythropoietin compromising erythropoiesis.
Mol Med
January 2025
Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Background: Lysinuric protein intolerance is a rare autosomal disorder caused by mutations in the Slc7a7 gene that lead to impaired transport of neutral and basic amino acids. The gold standard treatment for lysinuric protein intolerance involves a low-protein diet and citrulline supplementation. While this approach partially improves cationic amino acid plasma levels and alleviates some symptoms, long-term treatment is suggested to be detrimental and may lead to life-threatening complications characterized by a wide range of hematological and immunological abnormalities.
View Article and Find Full Text PDFComparative evaluation of calretinin immunohistochemical expression in calcifying odontogenic cyst and ameloblastoma.
BMC Oral Health
January 2025
Oral Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Background: Calretinin is a 29 kilodalton (KDa) calcium-binding protein that is expressed in normal and tumoral tissues. The expression of calretinin has been shown in the dental epithelium during odontogenesis and in different odontogenic cysts and tumors such as ameloblastoma. Since the epithelium of calcifying odontogenic cyst (COC) is similar to ameloblastoma and in both lesions, an arrangement of loose cells similar to stellate reticulum is seen, we aimed to investigate the comparative expression of calretinin in COC and ameloblastoma.
View Article and Find Full Text PDFAre medical school preclinical tests biased for sex and race? A differential item functioning analysis.
BMC Med Educ
January 2025
University of Minnesota Medical School, 420 Delaware Street SE, Mayo Building, Minneapolis, MN, 55455, USA.
Background: A common practice in assessment development, fundamental for fairness and consequently the validity of test score interpretations and uses, is to ascertain whether test items function equally across test-taker groups. Accordingly, we conducted differential item functioning (DIF) analysis, a psychometric procedure for detecting potential item bias, for three preclinical medical school foundational courses based on students' sex and race.
Methods: The sample included 520, 519, and 344 medical students for anatomy, histology, and physiology, respectively, collected from 2018 to 2020.
Determinants of rural practice among a cohort of dental professionals in Australia.
BMC Med Educ
January 2025
La Trobe Rural Health School, La Trobe University, Bendigo, VIC, 3550, Australia.
Background: Most research on tracking practice locations of health students has focused on medical students, particularly the factors influencing their choice to work in rural and remote areas. However, there is limited research on how rural origin and training in regional or rural settings affect the employment destinations of dental and oral health graduates. This paper explores the practice locations of dentistry and oral health therapy (OHT) graduates from rural backgrounds compared to those from metropolitan areas in Australia.
View Article and Find Full Text PDFHow does BMI correlate with menarche onset? Evidence from the Italian HBSC cross-sectional study.
BMC Womens Health
January 2025
Post Graduate School of Public Health, University of Siena, Siena, 53100, Italy.
Menarche is an important period in a female's life; its time of onset may depend on various factors and could correlate with the development of diseases in adulthood. Our study aims to investigate the relationship between body mass index and age at onset of menarche; METHODS: We used a unique standardized national dataset on adolescent girls participating in the Italian Health Behaviour in School-aged Children Study. Two independent nationally representative survey datasets: one on 15-year-olds (n = 6505, year 2017/2018) and one on 11-year-olds (n = 6548, year 2013/2014) were analysed.
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