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Osteoporotic bone fracture risk assessment in Latvian patients with newly diagnosed sarcoidosis.
Sarcoidosis Vasc Diffuse Lung Dis
June 2024
Department of Pathology, Riga Stradins University, Riga, Latvia.
Background And Aim: Increased calcitriol synthesis in sarcoid granulomas with subsequent hypercalcaemia and hypercalciuria can affect bone metabolism in patients with sarcoidosis. Multiple factors can increase the fracture risk in patients with sarcoidosis. This study aimed to evaluate a 10-year osteoporotic and a 10-year hip fracture risk and to analyse factors affecting fracture risk for patients with newly diagnosed sarcoidosis compared to an age- and gender-matched control group from a real-world setting.
View Article and Find Full Text PDFCalcium Chaos in Sarcoidosis: A Tale of Severe Hypercalcemia's Diagnostic Challenge.
Cureus
March 2024
Pulmonary and Critical Care Medicine, Saint Peter's University Hospital/Rutgers Robert Wood Johnson Medical School, New Brunswick, USA.
Sarcoidosis is a systemic inflammatory condition characterized by noncaseating granulomas. Lung involvement is typical, while extrapulmonary manifestations, notably lymphadenopathy, are observed in a significant proportion of cases. The etiology involves complex interactions among immune cells and mediators, resulting in granuloma formation capable of independently producing 1,25-dihydroxyvitamin D, leading to unregulated hypercalcemia and hypercalciuria.
View Article and Find Full Text PDFOrgan involvement in newly diagnosed sarcoidosis patients in the Netherlands: The first large European multicentre prospective study.
Respir Med
May 2024
Department of Respiratory Medicine, Zuyderland Medical Centre, Heerlen/Sittard, the Netherlands; Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, the Netherlands. Electronic address:
Background: Clinical presentation and prevalence of organ involvement is highly variable in sarcoidosis and depends on ethnic, genetic and geographical factors. These data are not extensively studied in a Dutch population.
Aim: To determine the prevalence of organ involvement and the indication for systemic immunosuppressive therapy in newly diagnosed sarcoidosis patients in the Netherlands.
Kidney manifestations of sarcoidosis.
J Autoimmun
December 2024
Department of Nephrology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Renal involvement is a clinically relevant organ manifestation of sarcoidosis, leading to increased morbidity and complications. Although the exact incidence remains unknown, renal disease is likely to occur in up to one third of all sarcoidosis patients. Every patient with newly diagnosed sarcoidosis should receive a renal work-up and screening for disrupted calcium metabolism.
View Article and Find Full Text PDFEfficacy of Oral Cinacalcet in Non-PTH Nonmalignant Hypercalcemia from Excess 1,25-Dihydroxyvitamin D.
JCEM Case Rep
March 2024
Division of Endocrinology, Diabetes, Metabolism, and Nutrition and Department of Medicine, Mayo College of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Elevated 1,25-dihydroxyvitamin D (1,25(OH)D) is a rare cause of non-parathyroid hormone (PTH)-mediated hypercalcemia seen in granulomatous disease, malignancy (most often lymphoma), or genetic mutations. Therapeutic options are limited. We report the case of a 67-year-old White man with nonmalignant, nongranulomatous, 1,25(OH)D-mediated hypercalcemia treated successfully with cinacalcet.
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