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| http://dx.doi.org/10.1172/JCI103373 | DOI Listing |
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Color doppler blood flow analysis in circumscribed choroidal hemangioma.
Arq Bras Oftalmol
January 2025
Department of Ophthalmology & Visual Sciences, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Purpose: To evaluate if color Doppler can detect internal blood flow in circumscribed choroidal hemangioma.
Methods: This cross-sectional study examined seven eyes of seven participants with circumscribed choroidal hemangiomas, with or without prior treatment. B-scan ultrasound and color Doppler were used to assess the dimensions, topographical distribution, and internal blood flow of the affected eyes.
Effects of intrathecal administration of sodium nitroprusside and nicardipine on cerebral pial microcirculation, cortical tissue oxygenation, and electrocortical activity in the early post-resuscitation period in a porcine cardiac arrest model.
PLoS One
January 2025
Department of Emergency Medicine, Chonnam National University Hospital, Gwangju, Republic of Korea.
Recent studies suggested intrathecal vasodilator administration as a therapy to mitigate post-ischemic cerebral hypoperfusion following cardiac arrest. We examined the effects of two commonly used intrathecal vasodilators, sodium nitroprusside (SNP) and nicardipine, on cerebral pial microcirculation, cortical tissue oxygen tension (PctO2), and electrocortical activity in the early post-resuscitation period using a porcine model of cardiac arrest. Thirty pigs were resuscitated after 14 min of untreated cardiac arrest.
View Article and Find Full Text PDFImproved Outcomes and Resource Use With Normothermic Machine Perfusion in Liver Transplantation.
JAMA Surg
January 2025
Division of Transplant Surgery, Department of Surgery, Mayo Clinic Arizona, Phoenix.
Importance: Normothermic machine perfusion (NMP) has been shown to reduce peritransplant complications. Despite increasing NMP use in liver transplant (LT), there is a scarcity of real-world clinical experience data.
Objective: To compare LT outcomes between donation after brain death (DBD) and donation after circulatory death (DCD) allografts preserved with NMP or static cold storage (SCS).
Prolonged sitting is not associated with altered shear-mediated dilation of the internal carotid artery, despite impairing lower limb endothelial function.
Physiol Rep
February 2025
Department of Biomedical Engineering, Toyo University, Saitama, Japan.
The present study aims to examine the effect of 4 h of continuous sitting on cerebral endothelial function, which is a crucial component of cerebral blood flow regulation. We hypothesized that 4 h of sitting may impair cerebral endothelial function similarly to how it affects lower limb vasculature. Thirteen young, healthy participants were instructed to remain seated for 4 h without moving their lower limbs.
View Article and Find Full Text PDFExploring the Structure-Activity Relationships of Albumin-Targeted Picoplatin-Based Platinum(IV) Prodrugs.
Inorg Chem
January 2025
Faculty of Chemistry, Institute of Inorganic Chemistry, University of Vienna, Waehringer Str. 42, 1090 Vienna, Austria.
Platinum(II) complexes prevail as first-line treatment for many cancers but are associated with serious side effects and resistance development. Picoplatin emerged as a promising alternative to circumvent GSH-induced tumor resistance by introducing a bulky 2-picoline ligand. Although clinical studies were encouraging, picoplatin did not receive approval.
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