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The environmental neurotoxin β-N-methylamino-l-alanine (l-BMAA) is deposited into birds' eggs.
Ecotoxicol Environ Saf
January 2018
Department of Environmental Toxicology, Uppsala University, SE-752 36 Uppsala, Sweden. Electronic address:
The neurotoxic amino acid β-N-methylamino-L-alanine (BMAA) has been implicated in the etiology of neurodegenerative disorders. BMAA is also a known developmental neurotoxin and research indicates that the sources of human and wildlife exposure may be more diverse than previously anticipated. The aim of the present study was therefore to examine whether BMAA can be transferred into birds' eggs.
View Article and Find Full Text PDFMinimally invasive (13)C-breath test to examine phenylalanine metabolism in children with phenylketonuria.
Mol Genet Metab
March 2016
Child & Family Research Institute, BC Children's Hospital, Vancouver, British Columbia, Canada; Department of Pediatrics, University of British Columbia, British Columbia, Canada; School of Population and Public Health, University of British Columbia, British Columbia, Canada. Electronic address:
Background: Phenylketonuria (PKU) is an autosomal recessive disorder caused by deficiency of hepatic phenylalanine hydroxylase (PAH) leading to increased levels of phenylalanine in the plasma. Phenylalanine levels and phenylalanine hydroxylase (PAH) activity monitoring are currently limited to conventional blood dot testing. 1-(13)C-phenylalanine, a stable isotope can be used to examine phenylalanine metabolism, as the conversion of phenylalanine to tyrosine occurs in vivo via PAH and subsequently releases the carboxyl labeled (13)C as (13)CO2 in breath.
View Article and Find Full Text PDFLocation of high and low affinity fatty acid binding sites on human serum albumin revealed by NMR drug-competition analysis.
J Mol Biol
August 2006
Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, 715 Albany Street Boston, MA 02118, USA.
Human serum albumin (HSA) is an abundant plasma protein that transports a wide variety of drugs and endogenous compounds. The complex binding capacity of HSA has made it a challenging system to study in detail but in order to develop our understanding of the interactions between ligands for HSA, the locations and relative affinities of different ligand binding sites must be determined. Albumin possesses multiple binding sites for its primary physiological ligand, non-esterified fatty acids (FA).
View Article and Find Full Text PDFDifferential oxidation of individual dietary fatty acids in humans.
Am J Clin Nutr
October 2000
Pennington Biomedical Research Center, Baton Rouge, LA 70808-4124, USA.
Background: Dietary fatty acids that are more prone to oxidation than to storage may be less likely to lead to obesity.
Objective: The aim of this study was to determine the effect of chain length, degree of unsaturation, and stereoisomeric effects of unsaturation on the oxidation of individual fatty acids in normal-weight men.
Design: Fatty acid oxidation was examined in men consuming a weight-maintenance diet containing 40% of energy as fat.
Biosynthesis, molecular structure, and domain architecture of potato suberin: a (13)C NMR study using isotopically labeled precursors.
J Agric Food Chem
August 2000
Department of Chemistry, Graduate School and College of Staten Island of the City University of New York, 10314, USA.
Although suberin in potato wound periderm is known to be a polyester containing long-chain fatty acids and phenolics embedded within the cell wall, many aspects of its molecular structure and polymer-polymer connectivities remain elusive. The present work combines biosynthetic incorporation of site-specifically (13)C-enriched acetates and phenylalanines with one- and two-dimensional solid-state (13)C NMR spectroscopic methods to monitor the developing suberin polymer. Exogenous acetate is found to be incorporated preferentially at the carboxyl end of the aliphatic carbon chains, suggesting addition during the later elongation steps of fatty acid synthesis.
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