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Density of eosinophils reflects activity of disease in allergic asthmatic children.
Clin Exp Allergy
December 1995
Department of Paediatrics, Sophia Children's Hospital, Rotterdam, Netherlands.
Background: Low density eosinophils are more prominent in asthmatic patients compared with healthy subjects. LDE are metabolically more active and produce more tissue-injuring and spasmogenic proteins than normal eosinophils.
Objective And Methods: With a method providing information about eosinophils of 12 different densities we were able to study eosinophil density characteristics in 24 young patients in detail with allergic asthma in a stable phase, and in 21 patients after a bronchial allergen challenge.
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