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Tomato fruit quality and nutrient dynamics under water deficit conditions: The influence of an organic fertilizer.
PLoS One
January 2025
Innovation Center of Zarnam Educators Research Industrial Group, Alborz Province, Hashtgerd City, Iran.
Drought adversely affects the growth and performance of plants. By contrast, the application of organic modifiers can improve plant growth by supplying nutrients and water. The influence of foliar application of organic fertilizer under water deficit conditions on growth traits, chemical composition, and fruit quality of tomato (Lycopersicon esculentum Mill.
View Article and Find Full Text PDFA PAS-targeting hERG1 activator reduces arrhythmic events in Jervell and Lange-Nielsen syndrome patient-derived hiPSC-CMs.
JCI Insight
January 2025
Department of Pharmacology, University of Michigan Medical School, Ann Arbor, United States of America.
The hERG1 potassium channel conducts the cardiac repolarizing current, IKr. hERG1 has emerged as a therapeutic target for cardiac diseases marked by prolonged actional potential duration (APD). Unfortunately, many hERG1 activators display off-target and proarrhythmic effects that limit their therapeutic potential.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Background: Whole genome methylation sequencing (WGMS) in blood identifies extensive differential DNA methylation between persons who are cognitively unimpaired (CU) and those with late-onset dementia due to Alzheimer's disease (AD). Here we investigate differentially methylated positions (DMPs) in persons with mild cognitive impairment (MCI) compared to persons with and without AD.
Method: WGMS data quantified DNA methylation levels at 25,406,945 CpG loci in 382 blood samples from 99 persons with MCI, 109 persons with AD and 174 cognitively unimpaired persons in the Wisconsin Alzheimer's Disease Research Center (WADRC) and the Wisconsin Registry for Alzheimer's Prevention (WRAP).
Public Health.
Alzheimers Dement
December 2024
Washington University in St. Louis, School of Medicine, St. Louis, MO, USA.
Background: The Exercise and Intensive Vascular Risk Reduction in Preventing Dementia (rrAD study) was a multicenter randomized, controlled trial to determine the effects of moderate to vigorous aerobic exercise training and intensive pharmacological treatment of cardiovascular risk factors on dementia prevention in older adults (NCT02913664). The trial duration was 2 years. We present herein the adverse events (AEs) reported in the rrAD trial.
View Article and Find Full Text PDFOptimized K Deposition Dynamics via Potassiphilic Porous Interconnected Mediators Coordinated by Single-Atom Iron for Dendrite-Free Potassium Metal Batteries.
Adv Sci (Weinh)
January 2025
Department of Chemical Engineering, National Tsing Hua University, Hsinchu, 30013, Taiwan.
Potassium metal batteries are emerging as a promising high-energy density storage solution, valued for their cost-effectiveness and low electrochemical potential. However, understanding the role of potassiphilic sites in nucleation and growth remains challenging. This study introduces a single-atom iron, coordinated by nitrogen atoms in a 3D hierarchical porous carbon fiber (Fe─N-PCF), which enhances ion and electron transport, improves nucleation and diffusion kinetics, and reduces energy barriers for potassium deposition.
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