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Identification of Natural Terpenoid Compounds as Potential Inhibitors of Nucleoprotein of Influenza A Virus using in silico Approach: ADMET, Molecular Docking, and Molecular Dynamic Simulation.
Med Chem
January 2025
Laboratory of Biotechnology and Natural Resources Valorization, Faculty of Sciences of Agadir, Ibn Zohr University, Agadir, Morocco.
Background: We continue to struggle with the prevention and treatment of the influenza virus. The 2009 swine flu pandemic, caused by the H1N1 strain of influenza A, resulted in numerous fatalities. The threat of influenza remains a significant concern for global health, and the development of novel drugs targeting these viruses is highly desirable.
View Article and Find Full Text PDFA scoring system to predict resistance to ceftolozane/tazobactam in respiratory isolates of Pseudomonas aeruginosa.
J Antimicrob Chemother
January 2025
Department of Infectious Diseases and Clinical Microbiology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Objectives: To develop a scoring system to predict resistance to ceftolozane/tazobactam in Pseudomonas aeruginosa strains isolated from respiratory specimens.
Methods: A case-control study was conducted to evaluate the risk factors associated with resistance to ceftolozane/tazobactam. Patients with P.
Examining the impact of the exercise package on eye and neck strain (EPENS) among adolescents: A pre-experimental study at a selected preuniversity college in Mangalore.
J Educ Health Promot
November 2024
Department of Child Health Nursing, Nitte (Deemed to be University), Nitte Usha Institute of Nursing Sciences (NUINS), Mangalore, Karnataka, India.
Background: Electronic devices like laptops, desktops, and cell phones are now essential in modern life, especially for students, due to their convenience and time-saving benefits. However, concerns about social issues related to prolonged use, particularly among kids and teenagers, have arisen. This study aimed to evaluate the efficacy of an exercise package in mitigating symptoms of eye and neck strain among adolescents who are regular users of electronic devices.
View Article and Find Full Text PDFExtracellular vesicles of PCM 2675 and PCM 489: an introductory characteristic.
Extracell Vesicles Circ Nucl Acids
November 2024
Department of Comparative Biochemistry and Bioanalytics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków 30-387, Poland.
Extracellular vesicles (EVs) are involved in intercellular and interkingdom communication in the complex communities that constitute the niche-specific microbiome of the colonized host. Therefore, studying the structure and content of EVs produced by resident bacteria is crucial to understanding their functionality and impact on the host and other microorganisms. Bacterial EVs were isolated by differential centrifugation, their size and concentration were measured by transmission electron microscopy and nanoparticle tracking analysis, and the cargo proteins were identified by liquid chromatography coupled to tandem mass spectrometry.
View Article and Find Full Text PDFIdentifying internal and external shoulder rotation using a kirigami-based shoulder patch.
Wearable Technol
December 2024
College of Engineering, University of Michigan, Ann Arbor, MI, USA.
Internal and external rotation of the shoulder is often challenging to quantify in the clinic. Existing technologies, such as motion capture, can be expensive or require significant time to setup, collect data, and process and analyze the data. Other methods may rely on surveys or analog tools, which are subject to interpretation.
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