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Trends in Investigations for Suspected Head and Neck Carcinoma of the Unknown Primary: A HNCIG and IFHNOS International Survey of Practice.
Head Neck
January 2025
Institute of Head and Neck Studies and Education (InHANSE), Department of Cancer and Genomics, University of Birmingham, UK.
Background: The aim of this clinical survey was to assess variations in head and neck squamous cell carcinoma from an unknown primary (HNSCCUP) diagnostic practices across international centers.
Methods: Clinical practice survey of experts nominated by Head and Neck Cancer International Group (HNCIG) and International Federation of Head and Neck Oncologic Societies (IFHNOS).
Results: Responses were received from 48/49 (97.
Diagnosis and prognosis of different methods of tongue base mucosectomy for occult head and neck cancer: A systematic review and meta-analysis.
Medicine (Baltimore)
November 2024
Department of Oral and Maxillofacial Surgery, Zhongshan Hospital Affiliated to Dalian University, Dalian, Liaoning Province, People's Republic of China.
Article Synopsis
- Trans-oral robotic surgery (TORS) and trans-oral laser microsurgery (TLM) are effective methods for identifying unknown primary cancers in the head and neck area, with a focus on tonsillectomy techniques.
- A systematic review found that 65% of patients had their primary tumors identified using TORS and TLM, with better results from TLM compared to TORS, especially for HPV-related tumors.
- Complications were relatively low, with nasogastric/gastrostomy issues occurring in 6% of cases, and hospitalization varied between 1 to over 7 days.
Common Tongue Conditions in Primary Care.
Am Fam Physician
November 2024
University of North Carolina School of Medicine, Chapel Hill.
Tongue conditions occur in 15.5% of the US population. The most common tongue conditions are geographic tongue, fissured tongue, and black hairy tongue; these conditions do not require treatment.
View Article and Find Full Text PDFTransformation zone at the vallate papillae: a significant source of papillomavirus infection at the base of the tongue?
J Cancer Res Clin Oncol
November 2024
First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.
Objective: The aim of this study was to investigate whether the base of the tongue harbours a transformation zone (TZ), i.e., an initiation site for papillomavirus infection, analogous to that in the uterine cervix by examining the histological structure of Von Ebner's gland ducts in the vallate papillae.
View Article and Find Full Text PDFDecoding the Enigma: Harnessing HPV Testing for the Precision Care in Carcinoma Unknown Primary with Secondary Metastasis to the Neck in North Indian Population Undergoing TORS for Primary Identification.
Indian J Otolaryngol Head Neck Surg
August 2024
Department of Pathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Article Synopsis
- The study aimed to evaluate the significance of high-risk HPV testing in patients with unknown primary carcinoma but secondary metastasis to the neck, focusing on those who underwent surgical procedures for identification of the primary site.
- Conducted at a tertiary care center over one year, the study included patients with proven squamous cell carcinoma in the neck and involved various surgical and testing methods, including tonsillectomy and HPV RNA/DNA analysis.
- Results showed very low positivity rates for p16 (5.56% in tonsils, 0% in tongue, 2.78% in lymph nodes) and undetectable HPV DNA in tissues and blood, suggesting that detailed high-risk HPV analysis may not be crucial in this specific patient population
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