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ZnFe Layered Double Hydroxide Nanosheets Loaded with Cu Single-Atom Nanozymes with Multi-Enzyme-Like Catalytic Activities as an Effective Treatment for Bacterial Keratitis.
Adv Sci (Weinh)
January 2025
College of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
Bacterial keratitis (BK) is a type of corneal inflammation resulting from bacterial infection in the eye. Although nanozymes have been explored as promising materials in corneal wound healing, currently available nanozymes lack sufficient catalytic activity and the ability to penetrate bacterial biofilms, limiting their efficacy against the treatment of BK. To remedy this, ZnFe layered double hydroxide (ZnFe-LDH) nanosheets are loaded with Cu single-atom nanozymes (Cu-SAzymes) and aminated dextran (Dex-NH), resulting in the formation of the nanozyme DT-ZnFe-LDH@Cu, which possesses peroxidase (POD)-, oxidase (OXD)-, and catalase (CAT)-like catalytic activities.
View Article and Find Full Text PDFPhase Transition Process of Graphite to Diamond Induced by Monodispersed Tantalum Atoms at Ordinary Pressure.
Adv Sci (Weinh)
January 2025
College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou, 310014, P. R. China.
The transformation of graphite into diamond (2-10 nm) at ordinary pressure by monodispersed Ta atoms was recently reported, while the effects of Ta concentration on the transition process remain obscure. Here, by regulating the Ta wire treatment time, as well as the annealing time and temperature, larger diamond grians (5-20 nm) are successfully synthesized, and the transition process of graphite to diamond is revealed to vary with Ta concentration. Specifically, short Ta wire treatments (5-10 min) induce graphite to form a "circle" structure and transforms into diamond directly after annealing.
View Article and Find Full Text PDFDelivery of Islatravir via High Drug-Load, Long-acting Microarray Patches for the Prevention or Treatment of Human Immunodeficiency Virus.
Adv Healthc Mater
January 2025
School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, BT9 7BL, UK.
This research focuses on developing and characterizing islatravir-loaded dissolving microarray patches (MAPs) to provide an effective, minimally invasive treatment option for human immunodeficiency virus (HIV-1) prevention and treatment. The research involves manufacturing these MAPs using a double-casting approach, and conducting in vitro and in vivo evaluations. Results show that the MAPs have excellent needle fidelity, structural integrity, and mechanical strength.
View Article and Find Full Text PDFEfficacy of a topical live probiotic in improving skin health.
Int J Cosmet Sci
January 2025
Blis Technologies Limited, Dunedin, New Zealand.
Introduction: Micrococcus luteus is a commensal bacterial member of the human skin and is essential in keeping the balance among the various microbial flora of the skin. M. luteus strain Q24 or BLIS Q24™ was isolated from the skin of a healthy human adult and is known to produce a unique antimicrobial spectrum that is inhibitory towards pathogens associated with skin diseases.
View Article and Find Full Text PDFExploring microfluidics-based organoid interactions through analysis of albumin secretion.
Lab Chip
January 2025
State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Engineering, School of Chemical Engineering, Dalian University of Technology, #2 Linggong Road, Dalian, 116024, China.
Organoids-on-a-chip exhibit significant potential for advancing disease modeling, drug screening, and precision medicine, largely due to their capacity to facilitate interactions among organoids. However, the influence of chip design on these interactions remains poorly understood, primarily due to our limited knowledge of the mediators of communication and the complexity of interaction dynamics. This study demonstrates that analyzing albumin secretion from liver organoids within an organoids-on-a-chip system can provide a measure of the interaction intensity among organoids, offering valuable insights into how chip design influences these interactions.
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