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Dysregulation of the NLRP3 Inflammasome and Promotion of Disease by IL-1β in a Murine Model of Sandhoff Disease.
Cells
January 2025
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK.
Sandhoff disease (SD) is a progressive neurodegenerative lysosomal storage disorder characterized by GM2 ganglioside accumulation as a result of mutations in the gene, which encodes the β-subunit of the enzyme β-hexosaminidase. Lysosomal storage of GM2 triggers inflammation in the CNS and periphery. The NLRP3 inflammasome is an important coordinator of pro-inflammatory responses, and we have investigated its regulation in murine SD.
View Article and Find Full Text PDFProbing Magnetism in Self-Assembled Organometallic Complexes Using Kondo Spectroscopy.
ACS Nano
January 2025
Physikalisches Institut, Karlsruhe Institute of Technology, Karlsruhe 76131, Germany.
Article Synopsis
- Control of individual atomic spins is essential for advancements in spintronics, quantum sensing, and quantum information processing, with scanning tunneling microscopy (STM) being a effective tool for manipulation.
- The research presents a new method for self-assembling magnetic organometallic complexes using iron atoms and specific molecules (Cu(dbm) and FePc) on a silver substrate, effectively forming complexes that mimic metallocenes.
- Magnetic properties of these complexes show a notable Kondo effect, which is explained through density functional theory calculations indicating that the interaction between Fe 3d-orbitals and benzene π-orbitals enhances Kondo screening, offering insights for designing hybrid organometallic systems.
Exploring happiness factors with explainable ensemble learning in a global pandemic.
PLoS One
January 2025
Department of Sociology, Hajee Mohammad Danesh Science and Technology University, Dinajpur, Bangladesh.
Happiness is a state of contentment, joy, and fulfillment, arising from relationships, accomplishments, and inner peace, leading to well-being and positivity. The greatest happiness principle posits that morality is determined by pleasure, aiming for a society where individuals are content and free from suffering. While happiness factors vary, some are universally recognized.
View Article and Find Full Text PDFCell Identification, Characterization, and Documentation for Use in the Production of Biological Products.
Arch Razi Inst
June 2024
Razi Vaccine and Serum Research Institute, Agricultural Research Education and Extension Organization (AREEO), P.O. Box 31975-148, Karaj, Iran.
There is always a concern about the quality of cell-based products in terms of the contamination of the cells and their lack of efficiency. Therefore, it is of prime importance to ensure these cells' identity, purity, efficacy, and suitability for the production of biological products and diagnostic uses. Hence, cells must be identified, evaluated, documented, and stored to be used consistently and efficiently.
View Article and Find Full Text PDFRetinoic acid drives surface epithelium fate determination through the TCF7-MSX2 axis.
Cell Mol Life Sci
December 2024
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China.
Understanding how embryonic progenitors decode extrinsic signals and transform into lineage-specific regulatory networks to drive cell fate specification is a fundamental, yet challenging question. Here, we develop a new model of surface epithelium (SE) differentiation induced by human embryonic stem cells (hESCs) using retinoic acid (RA), and identify BMP4 as an essential downstream signal in this process. We show that the retinoid X receptors, RXRA and RXRB, orchestrate SE commitment by shaping lineage-specific epigenetic and transcriptomic landscapes.
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