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Single-Cell Multiomics Reveals TCR Clonotype-Specific Phenotype and Stemness Heterogeneity of T-ALL Cells.
Cell Prolif
December 2024
Department of Systems Biomedical Sciences, School of Medicine, Jinan University, Guangzhou, China.
T-cell acute lymphoblastic leukaemia (T-ALL) is a heterogeneous malignant disease with high relapse and mortality rates. To characterise the multiomics features of T-ALL, we conducted integrative analyses using single-cell RNA, TCR and chromatin accessibility sequencing on pre- and post-treatment peripheral blood and bone marrow samples of the same patients. We found that there is transcriptional rewiring of gene regulatory networks in T-ALL cells.
View Article and Find Full Text PDFAbnormal Exercise Gas Exchange Before Pulmonary Emboli Diagnosis.
Mayo Clin Proc Innov Qual Outcomes
December 2024
Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas and University of Texas Southwestern Medical Center, Dallas, TX.
A 20-year-old male underwent diagnostic testing due to unexplained shortness of breath and chest discomfort. He had no previous medical problems and was not taking any medications. Initial evaluations included cardiopulmonary exercise testing (CPET), which yielded results that were reported as normal.
View Article and Find Full Text PDFPalliative Care Pearls to Complement Your Geriatric Gems.
Gastroenterol Nurs
October 2024
Anessa M. Foxwell, PhD, MBE, MSN, CRNP, ACHPN, FPCN, is a Postdoctoral Fellow at NewCourtland Center for Transitions and Health, University of Pennsylvania School of Nursing; Oncology Nurse Practitioner at Clinical Practices of the University of Pennsylvania, Perelman Center for Advanced Medicine, Philadelphia; and Associate Fellow at Leonard Davis Institute for Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania.
Caring about the family caregiver: A mentored journey building on the legacy of Janice Kiecolt-Glaser's pioneering research on caregivers' immune health.
Compr Psychoneuroendocrinol
November 2024
Elaine Hubbard Center for Nursing Research on Aging, School of Nursing, Department of Psychiatry, Division of Geriatrics & Aging, Department of Medicine, School of Medicine and Dentistry, University of Rochester Medical Center, United States.
Dr. Janice Kiecolt-Glaser has had enormous impact on understanding immune and health risks for stressed and burdened caregivers of a family member living with Alzheimer's disease or related dementia (ADRD). Her scientific and educational influence continues through the generativity to which she was committed during her career, mentoring multiple graduate and postdoctoral mentees over many years.
View Article and Find Full Text PDFCLOVER (CLOstridium difficile Vaccine Efficacy tRial) Study: A Phase 3, Randomized Trial Investigating the Efficacy and Safety of a Detoxified Toxin A/B Vaccine in Adults 50 Years and Older at Increased Risk of Clostridioides difficile Infection.
Clin Infect Dis
December 2024
Pfizer, Ltd, Hurley, United Kingdom.
Background: Clostridioides difficile infection (CDI) causes substantial mortality and healthcare burden. We assessed the detoxified toxin-A/B PF-06425090 vaccine for primary CDI prevention.
Methods: This phase 3 observer-blinded study randomized (1:1) ≥50-year-olds at increased CDI risk (N = 17 535) to receive 3 PF-06425090 or placebo doses (0, 1, and 6 months).
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