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Background And Objective: Serum protein electrophoresis (SPEP) plays a critical role in diagnosing diseases associated with M-proteins. However, its clinical application is limited by a heavy reliance on experienced experts.
Methods: A dataset comprising 85,026 SPEP outcomes was utilized to develop artificial intelligence diagnostic models for the classification and localization of M-proteins.
Predicting the effectiveness of chemotherapy treatment in lung cancer utilizing artificial intelligence-supported serum N-glycome analysis.
Comput Biol Med
January 2025
Research Institute of Biomolecular and Chemical Engineering, University of Pannonia, Veszprem, Hungary; Horváth Csaba Memorial Laboratory of Bioseparation Sciences, Research Center for Molecular Medicine, Doctoral School of Molecular Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. Electronic address:
An efficient novel approach is introduced to predict the effectiveness of chemotherapy treatment in lung cancer by monitoring the serum N-glycome of patients combined with artificial intelligence-based data analysis. The study involved thirty-three lung cancer patients undergoing chemotherapy treatments. Serum samples were taken before and after the treatment.
View Article and Find Full Text PDFUnusual Cutaneous Manifestations in a Patient with a History of Hepatitis B: A Case of Scleromyxedema and Literature Review.
Clin Cosmet Investig Dermatol
January 2025
Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, Guangdong, People's Republic of China.
Scleromyxedema (SM) is a rare primary cutaneous mucinosis characterized by systemic papules and scleroderma-like manifestations, often associated with monoclonal gammopathy. We present the case of a 37-year-old male with SM who developed yellowish plaques on the neck and back over three years. Histopathological examination revealed mucin deposition, fibroblast proliferation, and fibrosis, supporting the diagnosis.
View Article and Find Full Text PDFLipid Metabolism Alterations in Hyperlipidemic Dogs with Biliary Tract or Endocrine Diseases.
Animals (Basel)
January 2025
Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of Korea.
Fasting hyperlipidemia results from lipid metabolism defects associated with alterations in specific lipoprotein classes. These changes may originate from genetic predispositions or underlying metabolic disorders, including cholestasis and endocrine diseases. This retrospective study aimed to analyze variations in lipoprotein electrophoresis (LPE) profiles in hyperlipidemic dogs and investigate the associations between biliary tract diseases, endocrine disorders, and lipid metabolism.
View Article and Find Full Text PDFBlastocystis ST1: Protein Profile and Specific Serum Immunoglobulin in Irritable Bowel Syndrome (IBS) Patients.
Acta Parasitol
January 2025
Department of Animal Biology, Faculty of Science, Damascus University, Damascus, Syria.
Purpose: Blastocystis sp. is a common enteric human parasite, which recently has been linked to gastrointestinal disorders i.e.
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