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A Challenging Diagnosis of Huntington's Disease With Mild Clinical Features: Case Report.
J Investig Med High Impact Case Rep
September 2024
Hayatabad Medical Complex, Peshawar, Pakistan.
Article Synopsis
- * A case study of a 38-year-old Pashtun man illustrates the challenges of diagnosing HD due to his mild symptoms, lack of family history, and the disease's lower prevalence in his region, complicating the clinical picture.
- * This case emphasizes the need for heightened awareness of HD in patients with chorea, regardless of parental history, and highlights the importance of researching HD's prevalence and diagnosis barriers globally, especially in underrepresented areas.
Sporadic ADPKD: Absence of Family History as an Indicator of Clinical Mildness.
Kidney Int Rep
September 2024
Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Introduction Self-medication is defined as the use of a medication or product to treat, alleviate, or prevent a condition or symptom of an illness or to promote health. Self-management is increasingly used for dermatological diseases, especially chronic inflammatory skin diseases. Hence, it is crucial to be aware of its prevalence and the leading factors of its usage.
View Article and Find Full Text PDFLate-Stage C-H Nitration of Unactivated Arenes by Fe(NO)·9HO in Hexafluoroisopropanol.
Org Lett
April 2024
Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, Hubei Key Laboratory of Materials Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, Hubei 430074, People's Republic of China.
Operationally simple and generally applicable arene nitration with cheap and easily accessible chemicals has been a long-sought transformation in the synthetic organic community. In this work, we realized this goal with nontoxic and inexpensive Fe(NO)·9HO as the nitro source and easily recyclable solvent hexafluoroisopropanol as the promotor via a network of hydrogen-bonding interactions. As a result of the relative mildness and high reliability of this protocol, late-stage nitration of various highly functionalized natural products and commercially available drugs was realized.
View Article and Find Full Text PDFPhotoinduced Cobalt Catalysis for the Reductive Coupling of Pyridines and Dienes Enabled by Paired Single-Electron Transfer.
Angew Chem Int Ed Engl
November 2023
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany.
Selective hydroarylation of dienes has potential to provide swift access to useful building blocks. However, most existing methods rely on dienes stabilised by an aromatic group and transmetallation or nucleophilic attack steps require electron-rich aryl coupling partners. As such, there are few examples which tolerate wide-spread heteroarenes such as pyridine.
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