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Therapeutic Potential of Shilong Qingxue Granule and Its Extract Against Glutamate Induced Neural Injury: Insights from In Vivo and In Vitro Models.
J Ethnopharmacol
January 2025
Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, Liaoning, China; College of Pharmacy, Shenzhen Technology University, Shenzhen, Guangdong, China. Electronic address:
Ethnopharmacological Relevance: Shilong Qingxue Granule (SQG), a traditional Chinese medicine, effectively treats the secondary neurological damage and functional deficits caused by cerebral hemorrhage, though its exact mechanism remains unclear.
Aim Of The Study: This study aimed to investigate the effects of SQG and its mechanisms.
Materials And Methods: we evaluated the effects of SQG and its extracts on glutamate induced nerve damage using in vivo and in vitro models.
Biotransformation of Ganoderma lucidum and Hericium erinaceus for ex vivo gut-brain axis modulation and mood-related outcomes in humans: CREB/BDNF signaling and microbiota-driven synergies.
J Ethnopharmacol
January 2025
Department of Biopharmacy, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland; Department of Biochemistry and Toxicology, University of Life Sciences, Akademicka 13, 20-950 Lublin, Poland. Electronic address:
Background: The human gut microbiota plays a crucial role in various aspects of health, extending beyond digestion and nutrient absorption. Ganoderma lucidum (Reishi) and Hericium erinaceus (Lion's Mane), traditional medicinal mushrooms, have garnered interest due to their potential to exert positive health effects. The aim of our study was to investigate the molecular impact of Reishi and Lion's Mane on mood regulation through the gut-brain axis.
View Article and Find Full Text PDFQuantitative analysis of Δ- and Δ-tetrahydrocannabinol metabolites and isomers: a rapid assay in urine by LC-MS/MS.
Anal Bioanal Chem
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Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
An increasing number of cannabis-related products have become available and entered the market, particularly those containing cannabidiol (CBD) and Δ-tetrahydrocannabinol (Δ-THC). Analytical methods for cannabinoids in urine have been described extensively in the literature. However, methods providing good resolution for distinguishing interferences from THC positional isomers are needed.
View Article and Find Full Text PDFScreening analysis of doping agents in horse urine and plasma with dilute and shoot using liquid chromatography high resolution mass spectrometry.
Analyst
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Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, 70803, USA.
Various technical methodologies are required to accurately detect substances of different chemical and pharmacological properties in biological samples, which are increasing in number and variety daily. Therefore, laboratories where many samples and different factors are analyzed simultaneously need methods with easy sample preparation, short analysis times and low analysis costs. In this study, the objective was to scan substances susceptible to chemical degradation, amenable to analysis without hydrolysis, and exhibiting short-term stability by employing a straightforward, expeditious, and cost-efficient method.
View Article and Find Full Text PDFSelective sensing of terbinafine hydrochloride using carbon-based electrodes: a green and sustainable electroanalytical method for pharmaceutical products.
Anal Methods
January 2025
ampere - Laboratório de Plataformas Eletroquímicas - Universidade Federal de Santa Catarina, Departamento de Química, 88040-900 Florianópolis, SC, Brazil.
Terbinafine hydrochloride (TBF) is a broad-spectrum antifungal used to treat various dermatophyte infections affecting the skin, hair, and nails. Accurate, sensitive, and affordable analytical methods are crucial for quantifying this drug. In this study, we report on the use of carbon-based electrodes for the electrochemical determination of TBF in pharmaceutical samples, including raw materials and tablets.
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