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Catch Bonds in Immunology.
Annu Rev Immunol
March 2025
1Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA; email:
Catch bonds are molecular bonds that last longer under force than slip bonds, which become shorter-lived under force. Although catch bonds were initially discovered in studies of leukocyte and bacterial adhesions two decades ago, they have since been found in many other contexts, including platelet binding to blood vessel walls during clotting, structural support within the cell and between cells, force transmission in the cell's machineries for motility and mechanotransduction, viral infection of host cells, and immunoreceptor mechanosensing. Catch bonds are strengthened by increasing force, which induces structural changes in one or both interacting molecules either locally or allosterically to enable additional contacts at their binding interface, thus lengthening bond lifetimes.
View Article and Find Full Text PDFEctopic expression of testis-specific transcription elongation factor in driving cancer.
Sci Adv
March 2025
Simpson Querrey Institute for Epigenetics and the Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
The testis-specific BET protein BRDT structurally resembles the ubiquitous BRD4 and is misexpressed in cancer, and we show that BRDT misexpression may affect lung cancer progression. BRDT knockdown in lung cancer cells slowed tumor growth and prolonged survival in a xenograft model. Comparative characterization of PTEFb complex participation and chromatin binding indicates BRD4-redundant and BRD4-distinct BRDT functions.
View Article and Find Full Text PDFReference intervals for holotranscobalamin and total vitamin B12 in 6-12-year-old children in Norway: the Health Oriented Pedagogical Project (HOPP).
Scand J Clin Lab Invest
March 2025
Department of Medical Biochemistry, Vestfold Hospital Trust, Tønsberg, Norway.
Vitamin B12 (B12) is essential for DNA synthesis in all cells and for the development and maintenance of a healthy nervous system. B12 is transported in the circulation bound to two carrier proteins, haptocorrin and transcobalamin, measured as the biomarkers total B12 and holotranscobalamin (holoTC). The latter measures the fraction of cobalamin available for tissue uptake and is considered to have a better sensitivity and specificity for diagnosing vitamin deficiency.
View Article and Find Full Text PDFAnticancer potential of purified laccase enzyme from Trametes versicolor: specific cytotoxicity against thyroid and endometrial cancer cells.
Mol Biol Rep
March 2025
Department of Biology, Faculty of Arts and Sciences, Kocaeli University, Kocaeli, 41001, Turkey.
Background: Cancer is one of the leading causes of death worldwide, highlighting the need to develop novel therapeutic strategies that are more effective and have fewer side effects than conventional treatments. Enzymatic cancer therapy is a promising approach due to its high specificity and minimal toxicity. Among the various enzymes, laccase, a widely used biocatalyst, has shown significant potential for anti-cancer applications due to its proliferation inhibitory properties.
View Article and Find Full Text PDFIntegrated virtual screening and compound generation targeting H275Y mutation in the neuraminidase gene of oseltamivir-resistant influenza strains.
Mol Divers
March 2025
Growdea Technologies Pvt. Ltd., Gurugram, Haryana, 122004, India.
Neuraminidase (NA) is an essential enzyme located at the outer layer of the influenza virus and plays a key role in the release of virions from infected cells. The rising incidence of global epidemics has made the urgent need for effective antiviral medications an urgent public health priority. Furthermore, the emergence of resistance caused by specific mutations in the influenza viral genome exacerbates the challenges of antiviral therapy.
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