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Benzenesulfonohydrazide-tethered non-fused and fused heterocycles as potential anti-mycobacterial agents targeting enoyl acyl carrier protein reductase (InhA) with antibiofilm activity.
RSC Adv
September 2024
Laboratory of Genetics and Physiology of Mycobacterium, Institute of Medical Biology of the Polish Academy of Sciences Lodz Poland
Because resistant variants of the disease are always emerging, tuberculosis is a global issue that affects economies. New antitubercular medications should be developed, and this can be done by inhibiting druggable targets. Enoyl acyl carrier protein (ACP) reductase (InhA) is a crucial enzyme for the survival of (MTB).
View Article and Find Full Text PDFCementless, Cruciate-Retaining Primary Total Knee Arthroplasty Using Conventional Instrumentation: Technical Pearls and Intraoperative Considerations.
JBJS Essent Surg Tech
September 2024
Department of Orthopaedic Surgery, The Johns Hopkins Hospital, Baltimore, Maryland.
Article Synopsis
- Total knee arthroplasty (TKA) is a common surgical procedure for patients with severe knee osteoarthritis, especially when non-surgical treatments fail, leading to significant improvements in pain, function, and quality of life.
- The procedure can use various components (cemented, cementless, or a hybrid) and is generally performed with a focus on mechanical alignment, although newer alignment strategies like gap and kinematic balancing are showing promising results in early studies.
- The preferred surgical technique for cementless TKA involves a specific patient positioning and incision approach, starting with the application of a thigh tourniquet and a parapatellar incision, ensuring proper alignment and access during the surgery.*
Comparative Proteomic Analysis of Capsule Proteins in Aminoglycoside-Resistant and Sensitive Mycobacterium tuberculosis Clinical Isolates: Unraveling Potential Drug Targets.
Int J Mycobacteriol
April 2024
Department of Biochemistry, ICMR-National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Agra, Uttar Pradesh, India.
Background: Tuberculosis (TB), a global infectious threat, has seen a concerning rise in aminoglycoside-resistant Mycobacterium tuberculosis (M.tb) strains. The potential role of capsule proteins remains largely unexplored.
View Article and Find Full Text PDFFirst case of evolved herbicide resistance in the holoparasite sunflower broomrape, Wallr.
Front Plant Sci
June 2024
Syngenta Crop Protection AG, Werk Rosental, Basel, Switzerland.
The development and commercialisation of sunflower varieties tolerant to acetolactate synthase (ALS)-inhibiting herbicides some 20 years ago provided farmers with an alternative method for the cost-effective control of . In 2020, however, two independent sunflower broomrape populations from Drama (GR-DRA) and Orestiada (GR-ORE), Greece, were reported to be heavily infested with after application of the ALS-inhibiting herbicide imazamox. Here we have investigated the race of GR-DRA and GR-ORE and determined the basis of resistance to imazamox in the two Greek samples.
View Article and Find Full Text PDFPolypharmacology-Driven Discovery and Design of Highly Selective, Dual and Multitargeting Inhibitors of - A Review.
Curr Drug Targets
September 2024
Laboratory for Organic Reactivity, Discovery and Synthesis (Rm. 410), Research Center for the Natural and Applied Sciences, University of Santo Tomas, Espana Blvd., Manila 1015, Philippines.
The increasing demand for novel antitubercular agents has been the main 'force' of many TB research efforts due to the uncontrolled growing number of drug-resistant strains of in the clinical setting. Many strategies have been employed to address the drug-resistant issue, including a trend that is gaining attention, which is the design and discovery of inhibitors that are either dual- or multitargeting. The multiple-target design concept is not new in medicinal chemistry.
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