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Dual-function paper-based biosensor for sensitive detection of hyaluronidase and human papillomavirus DNA using diffusion wet area as readout.
Biosens Bioelectron
March 2025
Institute for Advanced Study, Research Center for Differentiation and Development of TCM Basic Theory, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, 330004, China. Electronic address:
Herein, a novel dual-function paper-based biosensor using diffusion wet area as readout has been developed for simple and sensitive detection of hyaluronidase (HAase) and human papillomavirus (HPV) 16 DNA, respectively. The target-regulated-water absorption hydrogel synthesized by hyaluronic acid (HA) and single-stranded DNA (ssDNA) is chosen as an ideal material for diffusion wet area generation on paper. The hydrogel can be degraded through the enzymolysis of HA by HAase or the trans-cleavage of ssDNA by HPV DNA-activated CRISPR/cas12a system.
View Article and Find Full Text PDFPrecisely Controlling the Activation of an Iron-Locked Drug Generator in the Liver Sinusoid to Enhance Barrier Penetration and Reduction of Liver Fibrosis.
J Am Chem Soc
December 2024
School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230031, China.
Article Synopsis
- - The text discusses challenges in delivering antifibrotic drugs to the liver due to physical barriers and clearance mechanisms, prompting the development of a new delivery strategy aimed at treating liver fibrosis.
- - This strategy involves a combination of a drug generator called Pro-HAase, which is injected, and an oral iron chelator named deferasirox (DFX), creating a targeted release of antifibrotic agents specifically in the fibrotic liver.
- - The approach effectively reverses liver fibrosis while minimizing toxicity related to residual iron, showcasing a sophisticated method for overcoming drug delivery barriers in liver treatment, potentially guiding future designs for similar nanomaterial systems.
Stachys byzantina K. Koch (Lamiaceae) as a potential ingredient for delaying skin ageing and treating hyperpigmentation disorders in pharmaceutical products.
J Pharm Pharmacol
October 2024
Laboratory of Bioactive Natural Products, Department of Biochemistry, Institute of Biological Science, Federal University of Juiz de Fora, Juiz de Fora, MG, 36036-900, Brazil.
Objectives: This study aimed to investigate whether the plant species Stachys byzantina produces bioactives with the potential to delay the skin ageing process and treat hyperpigmentation conditions.
Methods: The antioxidant action was assessed by 2,2-diphenyl-1-picrylhydrazylradical scavenging, Griess reaction, oxygen radical absorption capacity, and β-carotene bleaching assays. Inhibitory activities for tyrosinase, hyaluronidase, and elastase enzymes were tested.
Recent Progress in Multifunctional Stimuli-Responsive Combinational Drug Delivery Systems for the Treatment of Biofilm-Forming Bacterial Infections.
Pharmaceutics
July 2024
Metropolitan Seoul Center, Korea Basic Science Institute (KBSI), Seoul 03759, Republic of Korea.
Article Synopsis
- - Drug-resistant infections are a major medical challenge, and while adaptive lab evolution helps anticipate these issues, it has limitations; novel drug delivery systems (DDSs) aim to address this.
- - Multi-stimuli responsive DDSs target specific bacterial infection sites by exploiting the acidic conditions of infected tissues, facilitating more effective drug delivery and pathogen elimination.
- - Recent advancements in nano-drug delivery systems (nDDSs) improve the effectiveness of antimicrobial treatments by targeting and delivering drugs directly to bacterial biofilms, while also exploring new methods like immune modulation and photothermal therapy for enhanced treatment options.
Hyaluronidase overcomes the extracellular matrix barrier to enhance local drug delivery.
Eur J Pharm Biopharm
October 2024
Marine College, Shandong University, Weihai, Shandong 264209, China. Electronic address:
The stratum corneum of the skin presents the initial barrier to transdermal penetration. The dense structure of the extracellular matrix (ECM) further impedes local drug dispersion. Hyaluronidase (HAase) is a key component for the degradation of glycosidic bonding sites in hyaluronic acid (HA) within the ECM to overcome this barrier and enhance drug dispersion.
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